| Title: | "F-series prostaglandin function as sex pheromones in the Korean salamander, Hynobius leechii" |
| Address: | "Division of Science Education, Kangwon National University, Chuncheon, Kangwon 200-701, South Korea" |
| Journal Title: | Comp Biochem Physiol A Mol Integr Physiol |
| DOI: | 10.1016/j.cbpa.2009.05.006 |
| ISSN/ISBN: | 1531-4332 (Electronic) 1095-6433 (Linking) |
| Abstract: | "In order to test whether prostaglandins (PGs) function as sex pheromones in Hynobius leechii, a salamander that externally fertilizes its eggs, we conducted electro-olfactogram (EOG) studies with 19 PGs, liquid chromatography tandem mass spectrometry (LC-MS/MS) analyses of female and male holding waters, and behavioral tests on selected PGs. Of the 19 PGs tested, only three induced strong EOG responses from both males and ovulated females: 15-epi-prostaglandin F2alpha (15(R)-PGF2alpha), 15-keto-prostaglandin F2alpha (15K-PGF2alpha), and 13,14-dihydro-15-keto-prostaglandin F2alpha (13,14-dh-15K-PGF2alpha). In the LC-MS/MS studies, samples of holding water from ovulated females contained higher concentrations of 15(R)-PGF2alpha, PGF2alpha, and 13,14-dh-15K-PGF2alpha than those from males or oviposited females. In the behavioral tests, only 15(R)-PGF2alpha and ovulated female holding water induced significant reproductive behavior from male salamanders. These results suggest that F-series prostaglandins function as sex pheromones in amphibians" |
| Keywords: | "Animals Chromatography, Liquid Electrophysiological Phenomena Female Male Oviposition/physiology Prostaglandins F/pharmacology/*physiology Sex Attractants/*physiology Sexual Behavior, Animal/drug effects/physiology Smell/physiology Tandem Mass Spectrometr;" |
| Notes: | "MedlineEom, Junho Jung, Young Rim Park, Daesik eng Research Support, Non-U.S. Gov't 2009/05/22 Comp Biochem Physiol A Mol Integr Physiol. 2009 Sep; 154(1):61-9. doi: 10.1016/j.cbpa.2009.05.006. Epub 2009 May 18" |
