« Previous AbstractThe level of putative carotenoid-binding proteins determines the body color in two species of endemic Lake Baikal amphipods    Next AbstractInhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family »

Environ Pollut

Title:		A full life-cycle bioassay with Cantareus aspersus shows reproductive effects of a glyphosate-based herbicide suggesting potential endocrine disruption
Author(s):		Druart C; Gimbert F; Scheifler R; de Vaufleury A;
Address:		"Department of Chrono-Environment, University of Bourgogne Franche-Comte, UMR CNRS 6249 usc INRA, 16 route de Gray, F-25030 Besancon Cedex, France. Electronic address: coline.druart@wanadoo.fr. Department of Chrono-Environment, University of Bourgogne Franche-Comte, UMR CNRS 6249 usc INRA, 16 route de Gray, F-25030 Besancon Cedex, France"
Journal Title:		Environ Pollut
Year:		2017
Volume:		20170407
Issue:
Page Number:		240 - 249
DOI:		10.1016/j.envpol.2017.03.061
ISSN/ISBN:		1873-6424 (Electronic) 0269-7491 (Linking)
Abstract:		"A full life-cycle (240 days) bioassay using the terrestrial snail, Cantareus aspersus, allowing exposure during embryogenesis and/or the growth and reproduction phases, was used to assess the effects of Bypass((R)), a glyphosate-based herbicide (GlyBH), on a range of endpoints, including parameters under endocrine control. As a positive control, a mixture (R-A) made of diquat (Reglone((R))) and nonylphenols (NP, Agral((R))), known for its endocrine disrupting effects in other organisms, was tested. At environmental concentrations, both pesticides (R-A mixture and GlyBH) enhanced growth but reduced reproduction. The R-A mixture acted mainly on the fecundity through a delay in egg-laying of approximately 20 days and a strongly reduced number of clutches. This latter dysfunction may be caused by a permanent eversion of the penis, suggesting a disrupting effect at the neuro-endocrine level, which prevented normal mating. GlyBH acted on fertility, possibly due to a decrease in the fertilization of eggs laid by adults exposed during their embryonic development. These results, associated with the absence of observed effects on gonad histology of GlyBH exposed snails, suggested that the underlying mechanisms are neuro-endocrine"
Keywords:		Animals Biological Assay Embryonic Development/drug effects Endocrine Disruptors/*toxicity Endocrine System/drug effects Fertility/drug effects Glycine/*analogs & derivatives/toxicity Gonads/drug effects Herbicides/*toxicity *Life Cycle Stages Male Reprod;
Notes:		"MedlineDruart, Coline Gimbert, Frederic Scheifler, Renaud de Vaufleury, Annette eng England 2017/04/12 Environ Pollut. 2017 Jul; 226:240-249. doi: 10.1016/j.envpol.2017.03.061. Epub 2017 Apr 7"