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Genomics

Title:		"Analysis of the vomeronasal receptor repertoire, expression and allelic diversity in swine"
Author(s):		Dinka H; Le MT; Ha H; Cho H; Choi MK; Choi H; Kim JH; Soundarajan N; Park JK; Park C;
Address:		"Department of Animal Biotechnology, Konkuk University, Gwangjin-gu, Seoul, South Korea. Department of Swine and Poultry Science, Korea National College of Agriculture and Fisheries, Jeonju-si, Jeollabuk-do, South Korea. Department of Animal Biotechnology, Konkuk University, Gwangjin-gu, Seoul, South Korea. Electronic address: chankyu@konkuk.ac.kr"
Journal Title:		Genomics
Year:		2016
Volume:		20151019
Issue:		5
Page Number:		208 - 215
DOI:		10.1016/j.ygeno.2015.10.003
ISSN/ISBN:		1089-8646 (Electronic) 0888-7543 (Linking)
Abstract:		"Here we report a comprehensive analysis of the vomeronasal receptor repertoire in pigs. We identified a total of 25 V1R sequences consisting of 10 functional genes, 3 pseudogenes, and 12 partial genes, while functional V2R and FPR genes were not present in the pig genome. Pig V1Rs were classified into three subfamilies, D, F, and J. Using direct high resolution sequencing-based typing of all functional V1Rs from 10 individuals of 5 different breeds, a total of 24 SNPs were identified, indicating that the allelic diversity of V1Rs is much lower than that of the olfactory receptors. A high expression level of V1Rs was detected in the vomeronasal organ (VNO) and testes, while a low expression level of V1Rs was observed in all other tissues examined. Our results showed that pigs could serve as an interesting large animal model system to study pheromone-related neurobiology because of their genetic simplicity"
Keywords:		"Animals *Evolution, Molecular Genome Pheromones/genetics Phylogeny Polymorphism, Single Nucleotide Pseudogenes Receptors, Odorant/*genetics/metabolism Swine/*genetics Vomeronasal Organ/*metabolism Pheromone Swine V1Rs Vno Vomeronasal receptors;"
Notes:		"MedlineDinka, Hunduma Le, Minh Thong Ha, Heekyun Cho, Hyesun Choi, Min-Kyeung Choi, Hojun Kim, Jin-Hoi Soundarajan, Nagasundarapandian Park, Jin-Ki Park, Chankyu eng 2015/10/21 Genomics. 2016 May; 107(5):208-15. doi: 10.1016/j.ygeno.2015.10.003. Epub 2015 Oct 19"