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Sensors (Basel)

Title:		Love Acoustic Wave-Based Devices and Molecularly-Imprinted Polymers as Versatile Sensors for Electronic Nose or Tongue for Cancer Monitoring
Author(s):		Dejous C; Hallil H; Raimbault V; Lachaud JL; Plano B; Delepee R; Favetta P; Agrofoglio L; Rebiere D;
Address:		"IMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, France. corinne.dejous@ims-bordeaux.fr. IMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, France. hamida.hallil-abbas@u-bordeaux.fr. IMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, France. vraimbau@laas.fr. LAAS, CNRS UPR 8001, 31031 Toulouse, France. vraimbau@laas.fr. IMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, France. jean-luc.lachaud@ims-bordeaux.fr. IMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, France. bernard.plano@ims-bordeaux.fr. Normandie Univ., UNICAEN, UNIROUEN, ABTE, 14000 Caen, France. raphael.delepee@unicaen.fr. Comprehensive Cancer Center François Baclesse, UNICANCER, 14076 Caen, France. raphael.delepee@unicaen.fr. ICOA, University Orléans, CNRS, CNRS UMR 7311, F-45067 Orléans, France. patrick.favetta@univ-orleans.fr. ICOA, University Orléans, CNRS, CNRS UMR 7311, F-45067 Orléans, France. luigi.agrofoglio@univ-orleans.fr. IMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, France. dominique.rebiere@ims-bordeaux.fr"
Journal Title:		Sensors (Basel)
Year:		2016
Volume:		20160620
Issue:		6
Page Number:		-
DOI:		10.3390/s16060915
ISSN/ISBN:		1424-8220 (Electronic) 1424-8220 (Linking)
Abstract:		"Cancer is a leading cause of death worldwide and actual analytical techniques are restrictive in detecting it. Thus, there is still a challenge, as well as a need, for the development of quantitative non-invasive tools for the diagnosis of cancers and the follow-up care of patients. We introduce first the overall interest of electronic nose or tongue for such application of microsensors arrays with data processing in complex media, either gas (e.g., Volatile Organic Compounds or VOCs as biomarkers in breath) or liquid (e.g., modified nucleosides as urinary biomarkers). Then this is illustrated with a versatile acoustic wave transducer, functionalized with molecularly-imprinted polymers (MIP) synthesized for adenosine-5'-monophosphate (AMP) as a model for nucleosides. The device including the thin film coating is described, then static measurements with scanning electron microscopy (SEM) and electrical characterization after each step of the sensitive MIP process (deposit, removal of AMP template, capture of AMP target) demonstrate the thin film functionality. Dynamic measurements with a microfluidic setup and four targets are presented afterwards. They show a sensitivity of 5 Hz.ppm(-1) of the non-optimized microsensor for AMP detection, with a specificity of three times compared to PMPA, and almost nil sensitivity to 3'AMP and CMP, in accordance with previously published results on bulk MIP"
Keywords:		Biosensing Techniques/*methods Electronic Nose Humans Molecular Imprinting/methods Neoplasms/*diagnostic imaging Polymers/*chemistry Mip cancer biomarker chemical sensor electronic tongue microfluidic nucleoside surface acoustic wave urinary;
Notes:		"MedlineDejous, Corinne Hallil, Hamida Raimbault, Vincent Lachaud, Jean-Luc Plano, Bernard Delepee, Raphael Favetta, Patrick Agrofoglio, Luigi Rebiere, Dominique eng Switzerland 2016/06/23 Sensors (Basel). 2016 Jun 20; 16(6):915. doi: 10.3390/s16060915"