| Title: | "[The female pheromone 2,5-dimethylpyrazine induces sperm head abnormalities in male CBA mice]" |
| Address: | "Department of Genetics and Breeding, St. Petersburg State University, St. Petersburg, 199034 Russia. edaev@hotmail.com" |
| ISSN/ISBN: | 0016-6758 (Print) 0016-6758 (Linking) |
| Abstract: | "The effect of the house mouse female pheromone 2,5-dimethylpyrazine (2,5-DMP) on sperm differentiation in male CBA mice has been studied. For this purpose, mature males were treated with a 0.01% aqueous solution of the pheromone for six days. Control mice were similarly treated with physiologic saline. The mice were sacrificed 23 days after the treatment, and material for the analysis of sperm-head abnormalities was sampled from the caudal portion of the epididymis. Analysis of the frequency of abnormal sperms has demonstrated that the pheromonal treatment significantly increases the frequencies of various sperm-head abnormalities. Apparently, this results from disturbances in sex-cell differentiation germline cells caused by the induction of genetic damage at stages immediately preceding meiosis, as well as during the first and second meiotic divisions. The relationship between the effect of 2,5-DMP and the decrease in the fertility of male CBA mice that was earlier observed after a similar treatment is discussed" |
| Keywords: | "Animals Cell Differentiation/drug effects Female Housing, Animal Male Mice Mice, Inbred CBA Pyrazines/*pharmacology Sex Attractants/*pharmacology Sperm Head/*drug effects/*pathology Stress, Psychological;" |
| Notes: | "MedlineDaev, E V Dukel'skaia, A V rus English Abstract Russia (Federation) 2003/08/29 Genetika. 2003 Jul; 39(7):969-74" |
