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Genetika

Title:		[Cytogenetic effects of pheromones on bone marrow cells in male Mus musculus L. mice]
Author(s):		Daev EV; Sverdlova OL; Matskevich OA; Antoniuk EV;
Address:
Journal Title:		Genetika
Year:		1995
Volume:		31
Issue:		5
Page Number:		632 - 636
DOI:
ISSN/ISBN:		0016-6758 (Print) 0016-6758 (Linking)
Abstract:		"Young male CBA/LacStoRap mice were exposed for two hours to volatile components of native or dialyzed urine (VC or VCd, respectively) of mature males of the same line. To estimate the effects of VC and VCd on bone marrow cells, cytogenetic analysis of mitotic disturbances in anaphase-telophase cells was performed. The overall frequency of mitotic disturbances in VC-treated mice became significantly higher 24 and 48 h after exposure but returned to the initial level 72 h after exposure (P < 0.05). Similar effects were observed after 24 h in mice exposed to VCd. These results suggest that VC and VCd are capable of disturbing the stability of genetic processes in proliferating bone marrow cells. Evidence was also obtained that these components are associated with major urinary proteins. The significance and possible mechanisms of effects observed in the study are discussed"
Keywords:		"Animals Bone Marrow/*drug effects Bone Marrow Cells Chromosome Aberrations Male Mice Mice, Inbred CBA Mitosis/drug effects Sex Attractants/*toxicity/urine Volatilization;"
Notes:		"MedlineDaev, E V Sverdlova, O L Matskevich, O A Antoniuk, E V rus English Abstract Russia (Federation) 1995/05/01 Genetika. 1995 May; 31(5):632-6"