| Title: | Strategy for the multi-component characterization and quality evaluation of volatile organic components in Kaixin San by correlating the analysis by headspace gas chromatography/ion mobility spectrometry and headspace gas chromatography/mass spectrometry |
| Author(s): | Yin J; Lin R; Wu M; Ding H; Han L; Yang W; Song X; Li W; Qu H; Yu H; Li Z; |
| Address: | "College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China" |
| Journal Title: | Rapid Commun Mass Spectrom |
| ISSN/ISBN: | 1097-0231 (Electronic) 0951-4198 (Linking) |
| Abstract: | "RATIONALE: Kaixin San (KXS) is a prescription traditional Chinese medicine (TCM) with the effects of 'tonifying the kidney and brain' and 'improving memory'. The volatile organic compounds (VOCs) in KXS could effectively improve senile dementia and depression, but only few studies have focused on the overall characterization of VOCs in KXS and the quantitative study of the main active components. METHODS: We have developed a strategy to correlate the results from headspace gas chromatography/ion mobility spectrometry (HS-GC/IMS) and headspace gas chromatography/mass spectrometry (HS-GC/MS) for the comprehensive characterization of VOCs in KXS and the quantitative analysis of the main pharmacodynamic substances. RESULTS: A totsal of 68 low molecular weight VOCs were identified in KXS by HS-GC/IMS at room temperature and atmospheric pressure; 117 VOCs were identified and 10 components (isocalamenediol, alpha-asarone, beta-asarone, methyl eugenol, isoeugenol methyl ether, camphor, anethol, 2,4-di-tert-butylphol, linalool, asarylaldehyde) as the quality markers of KXS based on HS-GC/MS. CONCLUSIONS: This results from this study provide a foundation for quality control, pharmacodynamic mechanism research and further development of KXS, and provides more convincing data supporting the VOCs of other natural products" |
| Keywords: | "Drugs, Chinese Herbal/*chemistry Gas Chromatography-Mass Spectrometry/*methods Ion Mobility Spectrometry/*methods Quality Control Volatile Organic Compounds/*analysis;" |
| Notes: | "MedlineYin, Jiaxin Lin, Ruimei Wu, Mengfan Ding, Hui Han, Lifeng Yang, Wenzhi Song, Xinbo Li, Wenlong Qu, Haibin Yu, Heshui Li, Zheng eng 82074276/National Natural Science Foundation of China/ 2018ZX09721005/National Science and Technology Major Project of China/ 0610-2040NF020928/Projects of International Cooperation of Traditional Chinese Medicine/ England 2021/08/06 Rapid Commun Mass Spectrom. 2021 Nov 15; 35(21):e9174. doi: 10.1002/rcm.9174" |
