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Methods Mol Biol

Title:		Yeast mating: a model system for studying cell and nuclear fusion
Author(s):		Ydenberg CA; Rose MD;
Address:		"Department of Molecular Biology, Princeton University, Princeton, NJ, USA"
Journal Title:		Methods Mol Biol
Year:		2008
Volume:		475
Issue:
Page Number:		3 - 20
DOI:		10.1007/978-1-59745-250-2_1
ISSN/ISBN:		1064-3745 (Print) 1064-3745 (Linking)
Abstract:		"Haploid yeast cells mate to form a zygote, whose progeny are diploid cells. A fundamentally sexual event, related to fertilization, yeast mating nevertheless exhibits cytological properties that appear similar to somatic cell fusion. A large collection of mutations that lead to defects in various stages of mating, including cell fusion, has allowed a detailed dissection of the overall pathway. Recent advances in imaging methods, together with powerful methods of genetic analysis, make yeast mating a superb platform for investigation of cell fusion. An understanding of yeast cell fusion will provide insight into fundamental mechanisms of cell signaling, cell polarization, and membrane fusion"
Keywords:		"Cell Adhesion Cell Membrane/metabolism Cell Nucleus/*metabolism Cell Polarity Cell Wall/metabolism *Membrane Fusion *Models, Biological Pheromones/metabolism Reproduction Saccharomyces cerevisiae/*cytology/physiology Signal Transduction;"
Notes:		"MedlineYdenberg, Casey A Rose, Mark D eng R01 GM037739/GM/NIGMS NIH HHS/ 2008/11/04 Methods Mol Biol. 2008; 475:3-20. doi: 10.1007/978-1-59745-250-2_1"