« Previous AbstractDifferences in embryonic development in sensitive and resistant matings to pregnancy block stimuli in mice    Next AbstractEffects of operational conditions on sludge degradation and organic acids formation in low-critical wet air oxidation »

Molecules

Title:		Characterization of New Polyphenolic Glycosidic Constituents and Evaluation of Cytotoxicity on a Macrophage Cell Line and Allelopathic Activities of Oryza sativa
Author(s):		Chung IM; Kwon C; An Y; Ali M; Lee H; Lim JD; Kim S; Yang Y; Kim SH; Ahmad A;
Address:		"Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. imcim@konkuk.ac.kr. Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. chang794@konkuk.ac.kr. Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. ayj3043@konkuk.ac.kr. Department of Pharmacognosy and Phytochemistry, Hamdard University, New Delhi 110062, India. maliphyto@gmail.com. Department of Herbal Medicine Resource, Kangwon National University, Samcheok 25949, Korea. dlgkssk1009@naver.com. Department of Herbal Medicine Resource, Kangwon National University, Samcheok 25949, Korea. ijdae@kangwon.ac.kr. Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. hellosy1@konkuk.ac.kr. Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. jin9031@konkuk.ac.kr. Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. kshkim@konkuk.ac.kr. Process Chemistry and Technology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India. ateeque97@gmail.com"
Journal Title:		Molecules
Year:		2018
Volume:		20180802
Issue:		8
Page Number:		-
DOI:		10.3390/molecules23081933
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Four new constituents, as 5, 7-dihydroxy-4'-methoxyflavonol-3-O-beta-d-arabinopyranosyl-(2''-->1''')-O-beta-d-arabinopyrnosyl-2'''-O-3'''', 7''''-dimethylnonan-1''''-oate (1), 5-hydroxy-7, 4'-dimethoxyflavone-5-O-alpha-d-arabinopyranosyl-(2'-->1''')-O-alpha-d-arabinopyranosyl-2'''-O-3'''', 7''''-dimethylnonan-1''''-oate (2), 5-hydroxy-7, 4'-dimethoxyflavone-5-O-beta-d-arabinofuranosyl-(2'-->1''')-O-beta-d-arabinopyranosyl-2'''-O-lanost-5-ene (3) and 4',4''-diferuloxy feruloyl-O-alpha-d-arabinopyranosyl-(2a-->1b)-O-alpha-d-arabinopyranosyl-(2b-->1c)-O-alpha-d-arabinopyranosyl-(2c-->1d)-O-alpha-d-arabinopyranosyl-(2d-->1e)-O-alpha-d-arabinopyranosyl-2e-3''', 7'''-dimethylnonan-1'''-oate (4), along with three known compounds (5(-)7) were isolated from Oryza sativa leaves and straw. The structures of new and known compounds were elucidated by 1D ((1)H and (13)C NMR) and 2D NMR spectral methods, viz: COSY, HMBC, and HSQC aided by mass techniques and IR spectroscopy. The cytotoxicity of these constituents was assessed by using (RAW 264.7) mouse macrophage cell line, and allelopathic effects of compounds (1(-)7) on the germination and seedling growth characteristics such as seedling length and root length of barnyardgrass (Echinochloa oryzicola) were evaluated. Significant inhibitory activity was exhibited by compounds comprising flavone derivatives such as (1(-)3) on all of seed germination characteristics. The allelopathic effect of flavone derivatives were more pronounced on seedling length and root length than the germination characteristics. The higher concentration of flavone derivatives showed stronger inhibitory effects, whereas the lower concentrations showed stimulatory effects in some cases"
Keywords:		Animals Biphenyl Compounds/chemistry Carbon-13 Magnetic Resonance Spectroscopy Cell Death/drug effects Cell Survival/drug effects Free Radical Scavengers/chemistry Germination/drug effects Glycosides/chemistry/*toxicity Macrophages/*cytology/drug effects/;
Notes:		"MedlineChung, Ill-Min Kwon, Chang An, Yeonju Ali, Mohd Lee, Hannah Lim, Jung-Dae Kim, Soyeon Yang, Yujin Kim, Seung-Hyun Ahmad, Ateeque eng Switzerland 2018/08/04 Molecules. 2018 Aug 2; 23(8):1933. doi: 10.3390/molecules23081933"