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Fungal Genet Biol

Title:		Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans
Author(s):		Waugh MS; Vallim MA; Heitman J; Alspaugh JA;
Address:		"Department of Medicine, Duke University Medical Center, 1543 Busse Building, DUMC 3355, Durham, NC 27710, USA"
Journal Title:		Fungal Genet Biol
Year:		2003
Volume:		38
Issue:		1
Page Number:		110 - 121
DOI:		10.1016/s1087-1845(02)00518-2
ISSN/ISBN:		1087-1845 (Print) 1087-1845 (Linking)
Abstract:		"The Cryptococcus neoformans Ras1 signal transduction pathway controls mating, hyphal differentiation, and the ability of this opportunistic human fungal pathogen to grow at elevated temperatures. To further elucidate how Ras1 signals in this organism, the RAS1 gene was disrupted in the congenic serotype D strain background. Genetic epistasis experiments indicated that Ras1 regulates the mating response through the MAP kinase/pheromone response pathway. In fact, Ras1 is required for the transcriptional induction of elements of the pheromone response pathway. However, the ability of C. neoformans Ras1 to allow growth at 37 degrees C is mediated by a separate signaling pathway. Therefore a single Ras protein may differentially activate distinct downstream targets in response to different signals within the same organism. This conserved signaling motif has been coopted in C. neoformans to regulate mating and morphogenesis in addition to being required for its pathogenic potential"
Keywords:		"Crosses, Genetic Cryptococcus neoformans/genetics/*physiology *Fungal Proteins Gene Expression Regulation, Fungal MAP Kinase Signaling System/genetics Pheromones/*biosynthesis/genetics Signal Transduction/physiology ras Proteins/*physiology;"
Notes:		"MedlineWaugh, Michael S Vallim, Marcelo A Heitman, Joseph Alspaugh, J Andrew eng AI42159/AI/NIAID NIH HHS/ AI41937/AI/NIAID NIH HHS/ AI39115/AI/NIAID NIH HHS/ P01 AI44975/AI/NIAID NIH HHS/ AI01556/AI/NIAID NIH HHS/ P01 AI044975/AI/NIAID NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 2003/01/30 Fungal Genet Biol. 2003 Feb; 38(1):110-21. doi: 10.1016/s1087-1845(02)00518-2"