| Title: | Yolk-Water Partitioning of Neutral Organic Compounds in the Model Organism Danio rerio |
| Author(s): | Ulrich N; Schweiger N; Pfennigsdorff A; Scholz S; Goss KU; |
| Address: | "Department of Analytical Environmental Chemistry, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany. Department of Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany. Institute of Chemistry, University of Halle-Wittenberg, Halle, Germany" |
| ISSN/ISBN: | 1552-8618 (Electronic) 0730-7268 (Linking) |
| Abstract: | "Yolk is the most important temporary biological compartment of the early life stages of fish embryos. The sorption strength of a chemical to yolk components may significantly influence the distribution of that chemical in the fish embryo. We determined yolk-water partition coefficients (K(yolk/water) , in liters of water per kilogram of yolk, normalized to dry wt) for 70 neutral organic chemicals. The log K(yolk/water) values range from 0.76 to 6.56. On the basis of these values, we developed polyparameter linear free energy relationship models to predict yolk-water partitioning for a broad range of neutral organic chemicals with a root mean squared error of 0.37 and r(2) of 0.919. These models can be applied for the prediction of internal concentrations at equilibrium (neglecting biotransformation and active transport) in the zebrafish embryo test system. Environ Toxicol Chem 2020;39:1506-1516. (c) 2020 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC" |
| Keywords: | "Animals Biomass Dialysis Egg Proteins/analysis Egg Yolk/*chemistry *Models, Biological Organic Chemicals/*chemistry Reproducibility of Results Temperature Volatile Organic Compounds/analysis Water/*chemistry Water Pollutants, Chemical/chemistry Zebrafish/;" |
| Notes: | "MedlineUlrich, Nadin Schweiger, Nicole Pfennigsdorff, Andrea Scholz, Stefan Goss, Kai-Uwe eng 2020/05/10 Environ Toxicol Chem. 2020 Aug; 39(8):1506-1516. doi: 10.1002/etc.4744. Epub 2020 Jul 6" |
