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Cancer Epidemiol Biomarkers Prev

Title:		"Biomarkers of Exposure among Adult Smokeless Tobacco Users in the Population Assessment of Tobacco and Health Study (Wave 1, 2013-2014)"
Author(s):		Cheng YC; Reyes-Guzman CM; Christensen CH; Rostron BL; Edwards KC; Wang L; Feng J; Jarrett JM; Ward CD; Xia B; Kimmel HL; Conway K; Leggett C; Taylor K; Lawrence C; Niaura R; Travers MJ; Hyland A; Hecht SS; Hatsukami DK; Goniewicz ML; Borek N; Blount BC; van Bemmel DM;
Address:		"Center for Tobacco Products, Food and Drug Administration, Beltsville, Maryland. Yu-Ching.Cheng@fda.hhs.gov. Center for Tobacco Products, Food and Drug Administration, Beltsville, Maryland. National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Westat, Rockville, Maryland. US Centers for Disease Control and Prevention, Atlanta, Georgia. National Institute on Drug Abuse, National Institutes of Health, Rockville, Maryland. New York University College of Global Public Health, New York, New York. Roswell Park Cancer Institute, Buffalo, New York. University of Minnesota, Masonic Cancer Center, Minneapolis, Minnesota"
Journal Title:		Cancer Epidemiol Biomarkers Prev
Year:		2020
Volume:		20200127
Issue:		3
Page Number:		659 - 667
DOI:		10.1158/1055-9965.EPI-19-0766
ISSN/ISBN:		1538-7755 (Electronic) 1055-9965 (Print) 1055-9965 (Linking)
Abstract:		"BACKGROUND: Monitoring population-level toxicant exposures from smokeless tobacco (SLT) use is important for assessing population health risks due to product use. In this study, we assessed tobacco biomarkers of exposure (BOE) among SLT users from the Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health (PATH) Study. METHODS: Urinary biospecimens were collected from adults ages 18 and older. Biomarkers of nicotine, tobacco-specific nitrosamines (TSNA), polycyclic aromatic hydrocarbons (PAH), volatile organic compounds (VOC), metals, and inorganic arsenic were analyzed and reported among exclusive current established SLT users in comparison with exclusive current established cigarette smokers, dual SLT and cigarette users, and never tobacco users. RESULTS: In general, SLT users (n = 448) have significantly higher concentrations of BOE to nicotine, TSNAs, and PAHs compared with never tobacco users; significant dose-response relationships between frequency of SLT use and biomarker concentrations were also reported among exclusive SLT daily users. Exclusive SLT daily users have higher geometric mean concentrations of total nicotine equivalent-2 (TNE2) and TSNAs than exclusive cigarette daily smokers. In contrast, geometric mean concentrations of PAHs and VOCs were substantially lower among exclusive SLT daily users than exclusive cigarette daily smokers. CONCLUSIONS: Our study produced a comprehensive assessment of SLT product use and 52 biomarkers of tobacco exposure. Compared with cigarette smokers, SLT users experience greater concentrations of some tobacco toxicants, including nicotine and TSNAs. IMPACT: Our data add information on the risk assessment of exposure to SLT-related toxicants. High levels of harmful constituents in SLT remain a health concern"
Keywords:		Adolescent Adult Biomarkers/urine Carcinogens/analysis/toxicity Female Humans Longitudinal Studies Male Middle Aged Nicotine/toxicity/urine Nitrosamines Polycyclic Aromatic Hydrocarbons/toxicity/urine Prevalence Smokers/statistics & numerical data Tobacco;
Notes:		"MedlineCheng, Yu-Ching Reyes-Guzman, Carolyn M Christensen, Carol H Rostron, Brian L Edwards, Kathryn C Wang, Lanqing Feng, Jun Jarrett, Jeffery M Ward, Cynthia D Xia, Baoyun Kimmel, Heather L Conway, Kevin Leggett, Carmine Taylor, Kristie Lawrence, Charlie Niaura, Ray Travers, Mark J Hyland, Andrew Hecht, Stephen S Hatsukami, Dorothy K Goniewicz, Maciej L Borek, Nicolette Blount, Benjamin C van Bemmel, Dana M eng HHSN271201100027C/DA/NIDA NIH HHS/ HHSN271201600001C/DA/NIDA NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. 2020/01/29 Cancer Epidemiol Biomarkers Prev. 2020 Mar; 29(3):659-667. doi: 10.1158/1055-9965.EPI-19-0766. Epub 2020 Jan 27"