| Title: | Ultrasensitive silicon nanowire for real-world gas sensing: noninvasive diagnosis of cancer from breath volatolome |
| Author(s): | Shehada N; Bronstrup G; Funka K; Christiansen S; Leja M; Haick H; |
| Address: | "The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology , Haifa 3200003, Israel" |
| ISSN/ISBN: | 1530-6992 (Electronic) 1530-6984 (Linking) |
| Abstract: | "We report on an ultrasensitive, molecularly modified silicon nanowire field effect transistor that brings together the lock-and-key and cross-reactive sensing worlds for the diagnosis of (gastric) cancer from exhaled volatolome. The sensor is able to selectively detect volatile organic compounds (VOCs) that are linked with gastric cancer conditions in exhaled breath and to discriminate them from environmental VOCs that exist in exhaled breath samples but do not relate to the gastric cancer per se. Using breath samples collected from actual patients with gastric cancer and from volunteers who do not have cancer, blind analysis validated the ability of the reported sensor to discriminate between gastric cancer and control conditions with >85% accuracy, irrespective of important confounding factors such as tobacco consumption and gender. The reported sensing approach paves the way to use the power of silicon nanowires for simple, inexpensive, portable, and noninvasive diagnosis of cancer and other disease conditions" |
| Keywords: | *Breath Tests Humans Limit of Detection *Nanowires Neoplasms/*diagnosis Silicon/*chemistry Volatile Organic Compounds/*analysis Silicon nanowire breath cancer diagnosis field effect transistor volatile organic compound volatolome; |
| Notes: | "MedlineShehada, Nisreen Bronstrup, Gerald Funka, Konrads Christiansen, Silke Leja, Marcis Haick, Hossam eng Research Support, Non-U.S. Gov't 2014/12/17 Nano Lett. 2015 Feb 11; 15(2):1288-95. doi: 10.1021/nl504482t. Epub 2014 Dec 18" |
