| Title: | Volatile compounds detected in blood of drunk drivers by headspace/capillary gas chromatography/ion trap mass spectrometry |
| Address: | "National Laboratory of Forensic Chemistry, Toxicology Department, University Hospital, Linkoping, Sweden" |
| ISSN/ISBN: | 1052-9306 (Print) 1052-9306 (Linking) |
| Abstract: | "As shown by others, ethanol and methanol appear in the breath of normals, and endogenous methanol becomes detectable also in the blood after intake of ethanol. In this study I have investigated whether low-molecular-weight volatile organics, other than methanol, arise in the blood of drunk drivers who had imbibed alcoholic beverages. To this end a method for searching for such compounds in the blood is described. It was based on headspace extraction, gas chromatographic separation on a DB-WAX capillary, and ion trap detection in the mass range 29-99 u. Detection limits, as defined by the analyte concentration that gives a signal equal to three times the standard deviation of the baseline noise, were estimated for the different mass numbers used in the substance search. Given the detection limits, presented as mmoles per litre (numbers within parentheses), in every drunk driver's blood with more than 10 mmol l-1 of ethanol between seven and nine different volatile substances were spotted. These were ethanol (0.15), 2-propanone (0.015), ethyl acetate (0.0005), 2-butanone (0.006), methanol (1.5), 2-propanol (0.06), ethanol (0.7), 2-butanol (0.03), and 1-propanol (0.03)" |
| Keywords: | 1-Propanol/blood Acetaldehyde/blood Acetates/blood Acetone/blood Alcoholic Intoxication/*blood *Automobile Driving Butanols/blood Butanones/blood Ethanol/blood Gas Chromatography-Mass Spectrometry/methods Humans In Vitro Techniques Methanol/blood; |
| Notes: | "MedlineSchuberth, J eng England 1991/11/01 Biol Mass Spectrom. 1991 Nov; 20(11):699-702. doi: 10.1002/bms.1200201108" |
