| Title: | Synthesis of daumone derivatives and their antiangiogenic activities on chorioallantoic membrane |
| Author(s): | Ricci J; Min D; Oh M; Lim H; Chung WY; Park KK; Jung M; |
| Address: | "Department of Chemistry, Yonsei University, Seoul 120-749, Korea. mjung@yonsei.ac.kr" |
| DOI: | 10.2174/1573406411666150514100630 |
| ISSN/ISBN: | 1875-6638 (Electronic) 1573-4064 (Linking) |
| Abstract: | "Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents" |
| Keywords: | "Angiogenesis Inhibitors/*chemical synthesis/chemistry/*pharmacology Animals Chick Embryo Chickens Chorioallantoic Membrane/*drug effects Dose-Response Relationship, Drug Fatty Acids/*chemical synthesis/chemistry/*pharmacology Molecular Structure Pheromone;" |
| Notes: | "MedlineRicci, Jeremy Min, Dongguk Oh, Miyeon Lim, Hyenchong Chung, Won-Yoon Park, Kwang-Kyun Jung, Mankil eng Research Support, Non-U.S. Gov't Netherlands 2015/05/15 Med Chem. 2015; 11(8):747-52. doi: 10.2174/1573406411666150514100630" |
