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J Chem Neuroanat

Title:		Sex hormone binding globulin in the rat olfactory system
Author(s):		Ploss V; Gebhart VM; Dolz W; Jirikowski GF;
Address:		"Department of Anatomy II, University Hospital Jena, Friedrich Schiller University Jena, Germany. Department of Anatomy II, University Hospital Jena, Friedrich Schiller University Jena, Germany. Electronic address: Gustav.Jirikowski@med.uni-jena.de"
Journal Title:		J Chem Neuroanat
Year:		2014
Volume:		20140327
Issue:
Page Number:		10 - 14
DOI:		10.1016/j.jchemneu.2014.03.003
ISSN/ISBN:		1873-6300 (Electronic) 0891-0618 (Linking)
Abstract:		"Ovarian steroids are known to act on the olfactory system. Their mode of action, however, is mostly unclear to date since nuclear receptors are lacking in sensory neurons. Here we used immunocytochemistry and RT-PCR to study expression and distribution of sex hormone binding globulin (SHBG) in the rat olfactory system. Single sensory cells in the olfactory mucosa and their projections in the olfactory bulb showed specific SHBG immunostaining as determined by double immunofluorescence with olfactory marker protein OMP. Larger groups of SHBG stained sensory cells occurred in the vomeronasal organ (VNO). A portion of the olfactory glomeruli in the accessory olfactory bulb showed large networks of SHBG positive nerve fibres. Some of the mitral cells showed SHBG immune fluorescence. RT-PCR revealed SHBG encoding mRNA in the olfactory mucosa, in the VNO and in the olfactory bulbs indicating intrinsic expression of the binding globulin. The VNO and its related projections within the limbic system are known to be sensitive to gonadal steroid hormones. We conclude that SHBG may be of functional importance for rapid effects of olfactory steroids on limbic functions including the control of reproductive behaviours through pheromones"
Keywords:		"Animals Fluorescent Antibody Technique Hypothalamus/metabolism Male Olfactory Bulb/cytology/*metabolism Olfactory Marker Protein/metabolism Olfactory Mucosa/cytology/metabolism RNA, Messenger/biosynthesis/genetics Rats Sensory Receptor Cells/metabolism Se;"
Notes:		"MedlinePloss, V Gebhart, V M Dolz, W Jirikowski, G F eng Netherlands 2014/04/01 J Chem Neuroanat. 2014 May; 57-58:10-4. doi: 10.1016/j.jchemneu.2014.03.003. Epub 2014 Mar 27"