| Title: | Variation in volatile organic compounds in the breath of normal humans |
| Author(s): | Phillips M; Herrera J; Krishnan S; Zain M; Greenberg J; Cataneo RN; |
| Address: | "Menssana Research, Fort Lee, NJ 07024, USA. menssana@bellatlantic.net" |
| Journal Title: | J Chromatogr B Biomed Sci Appl |
| DOI: | 10.1016/s0378-4347(99)00127-9 |
| ISSN/ISBN: | 1387-2273 (Print) 1387-2273 (Linking) |
| Abstract: | "We studied the variation in volatile organic compounds (VOCs) in the breath of 50 normal humans, using gas chromatography and mass spectroscopy. An average breath sample contained 204.2 VOCs (SD=19.8, range 157-241). The alveolar gradient of each VOC (abundance in breath minus abundance in air) varied with rate of synthesis minus rate of clearance. A total of 3481 different VOCs were observed: 1753 with positive alveolar gradients, 1728 with negative alveolar gradients. Twenty-seven VOCs were observed in all fifty subjects. This study confirmed previous reports of wide inter-individual variations. Two new findings were the comparatively small variation in total number of breath VOCs, and the presence of a 'common core' of breath VOCs in all subjects" |
| Keywords: | *Breath Tests Gas Chromatography-Mass Spectrometry Humans Organic Chemicals/*analysis; |
| Notes: | "MedlinePhillips, M Herrera, J Krishnan, S Zain, M Greenberg, J Cataneo, R N eng Netherlands 1999/07/20 J Chromatogr B Biomed Sci Appl. 1999 Jun 11; 729(1-2):75-88. doi: 10.1016/s0378-4347(99)00127-9" |
