« Previous Abstract"SARS-CoV-2 and helminth co-infections, and environmental pollution exposure: An epidemiological and immunological perspective"    Next AbstractA review of strategies and their effectiveness in reducing indoor airborne transmission and improving indoor air quality »

Development

Title:		Smad4-dependent morphogenic signals control the maturation and axonal targeting of basal vomeronasal sensory neurons to the accessory olfactory bulb
Author(s):		Naik AS; Lin JM; Taroc EZM; Katreddi RR; Frias JA; Lemus AA; Sammons MA; Forni PE;
Address:		"Department of Biological Sciences; The RNA Institute; University at Albany, State University of New York, Albany, NY 12222, USA. Department of Biological Sciences; The RNA Institute; University at Albany, State University of New York, Albany, NY 12222, USA pforni@albany.edu"
Journal Title:		Development
Year:		2020
Volume:		20200427
Issue:		8
Page Number:		-
DOI:		10.1242/dev.184036
ISSN/ISBN:		1477-9129 (Electronic) 0950-1991 (Print) 0950-1991 (Linking)
Abstract:		"The vomeronasal organ (VNO) contains two main types of vomeronasal sensory neurons (VSNs) that express distinct vomeronasal receptor (VR) genes and localize to specific regions of the neuroepithelium. Morphogenic signals are crucial in defining neuronal identity and network formation; however, if and what signals control maturation and homeostasis of VSNs is largely unexplored. Here, we found transforming growth factor beta (TGFbeta) and bone morphogenetic protein (BMP) signal transduction in postnatal mice, with BMP signaling being restricted to basal VSNs and at the marginal zones of the VNO: the site of neurogenesis. Using different Smad4 conditional knockout mouse models, we disrupted canonical TGFbeta/BMP signaling in either maturing basal VSNs (bVSNs) or all mature VSNs. Smad4 loss of function in immature bVSNs compromises dendritic knob formation, pheromone induced activation, correct glomeruli formation in the accessory olfactory bulb (AOB) and survival. However, Smad4 loss of function in all mature VSNs only compromises correct glomeruli formation in the posterior AOB. Our results indicate that Smad4-mediated signaling drives the functional maturation and connectivity of basal VSNs"
Keywords:		"Animals Axons/*metabolism Bone Morphogenetic Proteins/metabolism Dendrites/metabolism GAP-43 Protein/metabolism Gene Deletion Integrases/metabolism Mice, Knockout *Morphogenesis Odorants Olfactory Bulb/*metabolism Presynaptic Terminals/metabolism Sensory;"
Notes:		"MedlineNaik, Ankana S Lin, Jennifer M Taroc, Ed Zandro M Katreddi, Raghu R Frias, Jesus A Lemus, Alex A Sammons, Morgan A Forni, Paolo E eng R01 DC017149/DC/NIDCD NIH HHS/ R01 HD097331/HD/NICHD NIH HHS/ R15 GM128049/GM/NIGMS NIH HHS/ R15 HD096411/HD/NICHD NIH HHS/ Research Support, N.I.H., Extramural England 2020/04/29 Development. 2020 Apr 27; 147(8):dev184036. doi: 10.1242/dev.184036"