« Previous AbstractRapid prototyping of carbon-based chemiresistive gas sensors on paper    Next Abstract"Selective determination of ethyl acetate, acetone, ethanol, and methyl ethyl ketone using quartz crystal nanobalance combined with principle component analysis" »

Biol Reprod

Title:		Prenatal exposure to di-(2-ethylhexyl) phthalate and high-fat diet synergistically disrupts mouse fetal oogenesis and affects folliculogenesisdagger
Author(s):		Mirihagalle S; You T; Suh L; Patel C; Gao L; Rattan S; Qiao H;
Address:		"Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA"
Journal Title:		Biol Reprod
Year:		2019
Volume:		100
Issue:		6
Page Number:		1561 - 1570
DOI:		10.1093/biolre/ioz051
ISSN/ISBN:		1529-7268 (Electronic) 0006-3363 (Print) 0006-3363 (Linking)
Abstract:		"Di-(2-ethylhexyl) phthalate (DEHP) is a chemical that is widely used as a plasticizer. Exposure to DEHP has been shown to alter ovarian function in humans. Additionally, foods high in fat content, regularly found in the western diet, have been shown to be another potential disruptor of fetal ovarian function. Due to DEHP's lipophilicity, high-fat foods can be easily contaminated. Therefore, exposure to DEHP and a high-fat diet are both health concerns, especially in pregnant women, and the effects of these exposures on fetal oocyte quality and quantity should be elucidated. In this study, our goal was to determine if there are synergistic effects of DEHP exposure at an environmentally relevant level (20 mug/kg body weight/day) and high-fat diet on oogenesis and folliculogenesis. Dams were fed with a high-fat diet (45 kcal% fat) or a control diet (10 kcal% fat) 1 week before mating and during pregnancy and lactation. The pregnant mice were dosed with DEHP (20 mug/kg body weight/day) or vehicle control from E10.5 to litter birth. We found that treatment with an environmentally relevant dosage of DEHP and consumption of high-fat diet significantly increases synapsis defects in meiosis and affects folliculogenesis in the F1 generation"
Keywords:		"Animals Diet, High-Fat/*adverse effects Dietary Fats/pharmacology Diethylhexyl Phthalate/*toxicity Drug Synergism Endocrine Disruptors/toxicity Female Fetus/*drug effects Gene Expression Regulation, Developmental/drug effects Gene Silencing/drug effects M;"
Notes:		"MedlineMirihagalle, Supipi You, Tianming Suh, Lois Patel, Chintan Gao, Liying Rattan, Saniya Qiao, Huanyu eng P01 ES022848/ES/NIEHS NIH HHS/ R00 HD082375/HD/NICHD NIH HHS/ T32 ES007326/ES/NIEHS NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. 2019/04/03 Biol Reprod. 2019 Jun 1; 100(6):1561-1570. doi: 10.1093/biolre/ioz051"