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Neuron

Title:		Pigment-dispersing factor modulates pheromone production in clock cells that influence mating in drosophila
Author(s):		Krupp JJ; Billeter JC; Wong A; Choi C; Nitabach MN; Levine JD;
Address:		"Department of Biology, University of Toronto at Mississauga, Mississauga, ON L5L1C6, Canada"
Journal Title:		Neuron
Year:		2013
Volume:		79
Issue:		1
Page Number:		54 - 68
DOI:		10.1016/j.neuron.2013.05.019
ISSN/ISBN:		1097-4199 (Electronic) 0896-6273 (Print) 0896-6273 (Linking)
Abstract:		"Social cues contribute to the circadian entrainment of physiological and behavioral rhythms. These cues supplement the influence of daily and seasonal cycles in light and temperature. In Drosophila, the social environment modulates circadian mechanisms that regulate sex pheromone production and mating behavior. Here we demonstrate that a neuroendocrine pathway, defined by the neuropeptide Pigment-Dispersing Factor (PDF), couples the CNS to the physiological output of peripheral clock cells that produce pheromones, the oenocytes. PDF signaling from the CNS modulates the phase of the oenocyte clock. Despite its requirement for sustaining free-running locomoter activity rhythms, PDF is not necessary to sustain molecular rhythms in the oenocytes. Interestingly, disruption of the PDF signaling pathway reduces male sex pheromones and results in sex-specific differences in mating behavior. Our findings highlight the role of neuropeptide signaling and the circadian system in synchronizing the physiological and behavioral processes that govern social interactions"
Keywords:		"Animals Behavior, Animal/physiology Biological Clocks/physiology Circadian Rhythm/*physiology Drosophila Drosophila Proteins/genetics/*metabolism Fatty Acid Desaturases/genetics/metabolism Motor Activity/physiology Neurons/*metabolism Neuropeptides/geneti;"
Notes:		"MedlineKrupp, Joshua J Billeter, Jean-Christophe Wong, Amy Choi, Charles Nitabach, Michael N Levine, Joel D eng R01NS055035/NS/NINDS NIH HHS/ R01 NS056443/NS/NINDS NIH HHS/ CAPMC/CIHR/Canada R56 NS055035/NS/NINDS NIH HHS/ R01NS056443/NS/NINDS NIH HHS/ R01 GM098931/GM/NIGMS NIH HHS/ R01 NS055035/NS/NINDS NIH HHS/ R01GM098931/GM/NIGMS NIH HHS/ R01 NS083875/NS/NINDS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2013/07/16 Neuron. 2013 Jul 10; 79(1):54-68. doi: 10.1016/j.neuron.2013.05.019"