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Biomed Phys Eng Express

Title:		"Taking leads out of nature, can nano deliver us from COVID-like pandemics?"
Author(s):		Kaur N; Sharma P; Aditya A; Shanavas A;
Address:		"Inorganic & Organic Nanomedicine Lab, Institute of Nano Science and Technology, Sector 81, Mohali, Punjab 140306, India"
Journal Title:		Biomed Phys Eng Express
Year:		2022
Volume:		20220218
Issue:		2
Page Number:		-
DOI:		10.1088/2057-1976/ac4ec8
ISSN/ISBN:		2057-1976 (Electronic) 2057-1976 (Linking)
Abstract:		"The COVID-19 crisis has alerted the research community to re-purpose scientific tools that can effectively manage emergency pandemic situations. Researchers were never so desperate to discover a 'magic bullet' that has significant clinical benefits with minimal or no side effects. At the beginning of the pandemic, due to restricted access to traditional laboratory techniques, many research groups delved into computational screening of thousands of lead molecules that could inhibit SARS-CoV-2 at one or more stages of its infectious cycle. Severalin silicostudies on natural derivatives point out their potency against SARS-CoV-2 proteins. However, theoretical predictions and existing knowledge on related molecules reflect their poor oral bioavailability due to biotransformation in the gut and liver. Nanotechnology has evolved into a key field for precise and controlled delivery of various drugs that lack aqueous solubility, have low oral bioavailability and possess pronounced toxicity in their native form. In this review, we discuss various nanoformulations of natural products with favorable ADME properties, and also briefly explore nano-drug delivery to lungs, the primary site of SARS-CoV-2 infection. Natural products are also envisioned to augment nanotechnology-based (1) personnel protective equipment forex vivoviral inactivation and (2) wearable sensors that perform rapid and non-invasive analysis of volatile organic compounds in exhaled breath of the infected person after therapeutic food consumption"
Keywords:		*covid-19 Humans Nanotechnology *Pandemics/prevention & control SARS-CoV-2 bioavailability natural derivatives personnel protective equipment pulmonary drug delivery toxicity wearable sensors;
Notes:		"MedlineKaur, Navneet Sharma, Priyanka Aditya, Adrija Shanavas, Asifkhan eng Review England 2022/01/26 Biomed Phys Eng Express. 2022 Feb 18; 8(2). doi: 10.1088/2057-1976/ac4ec8"