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J Vet Med Sci

Title:		Substances derived from 4-ethyl octanoic acid account for primer pheromone activity for the 'male effect' in goats
Author(s):		Iwata E; Kikusui T; Takeuchi Y; Mori Y;
Address:		"Laboratory of Veterinary Ethology, The University of Tokyo, Japan"
Journal Title:		J Vet Med Sci
Year:		2003
Volume:		65
Issue:		9
Page Number:		1019 - 1021
DOI:		10.1292/jvms.65.1019
ISSN/ISBN:		0916-7250 (Print) 0916-7250 (Linking)
Abstract:		"A major constituent of the characteristic 'goaty odor' 4-ethyl octanoic acid (4EOA) was previously shown to have no primer pheromone activity. This was also confirmed by our own bioassay system utilizing the recording technique of neural activity of the hypothalamic gonadotropin-releasing hormone pulse generator in goats. However, when the synthetic 4EOA solution was kept at room temperature for several months, primer pheromone activity appeared in the same solution. Headspace gas chromatography/mass spectrometry analysis revealed that there were several newly formed substances in addition to 4EOA samples with primer pheromone activity. These results suggest that 4EOA derived substance(s) but not 4EOA itself is(are) primer pheromone in goats"
Keywords:		Animals Caprylates/*analysis/chemistry Gas Chromatography-Mass Spectrometry Goats/*physiology Male Pheromones/*analysis Sex Characteristics;
Notes:		"MedlineIwata, Eri Kikusui, Takefumi Takeuchi, Yukari Mori, Yuji eng Research Support, Non-U.S. Gov't Japan 2003/10/09 J Vet Med Sci. 2003 Sep; 65(9):1019-21. doi: 10.1292/jvms.65.1019"