| Title: | "Phytochemistry and Antihyperglycemic Potential of Cistus salviifolius L., Cistaceae" |
| Author(s): | Hitl M; Bijelic K; Stilinovic N; Bozin B; Srdenovic-Conic B; Torovic L; Kladar N; |
| Address: | "Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. Department of Pharmacology and Toxicology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. Center for Medical and Pharmaceutical Investigations and Quality Control (CEMPhIC), Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia. Institute of Public Health of Vojvodina, 21000 Novi Sad, Serbia" |
| DOI: | 10.3390/molecules27228003 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "Cistus salviifolius has been previously reported as a traditional remedy for hyperglycemia. However, the plant has been scarcely investigated from scientific point of view. Thus, the aim was to examine the chemical composition and to evaluate its antioxidant and antihyperglycemic potential in vitro. Aqueous and ethanolic extracts were evaluated for total phenolic, tannin, and flavonoid content using spectrophotometric methods. Detailed chemical characterization was performed by high-performance liquid chromatography (HPLC-DAD). The volatile organic compounds (VOCs) profile was assessed by gas chromatography technique. The potential in diabetes treatment was evaluated through tests of free radicals neutralization, inhibition of lipid peroxidation process, and test of ferric ion reduction; activity in tests of inhibition of alpha-amylase, alpha-glucosidase and dipeptidyl peptidase-4 was also evaluated. High content of phenolics (majority being tannins) was detected; detailed HPLC analysis revealed high content of gallic acid, followed by rutin, chlorogenic and caffeic acids. The VOCs analysis determined sesquiterpene hydrocarbons and oxygenated sesquiterpenes as the main groups of compounds. The assays classified extracts as potent neutralizers of 2,2-diphenyl-1-picrylhydrazil and nitroso radicals formation and potent inhibitors of alpha-amylase and alpha-glucosidase. In conclusion, Cistus salviifolius represents a rich source of phenolics and essential oil with sesquiterpenes. The established results suggested its promising antioxidant and antihyperglycemic activities" |
| Keywords: | *Cistus/chemistry Hypoglycemic Agents/pharmacology/chemistry *Cistaceae Antioxidants/pharmacology/chemistry alpha-Glucosidases/chemistry Plant Extracts/pharmacology/chemistry alpha-Amylases Phenols/chemistry Tannins Gc-ms Hplc-dad antihyperglycemic antiox; |
| Notes: | "MedlineHitl, Maja Bijelic, Katarina Stilinovic, Nebojsa Bozin, Biljana Srdenovic-Conic, Branislava Torovic, Ljilja Kladar, Nebojsa eng 451-03-68/2020-14/200114/Ministry of Education, Science and Technological Development, Republic of Serbia/ 142-451-2550/2021-01/Provincial Secretariat for Higher Education and Scientific Research, AP Vojvodina/ Switzerland 2022/11/27 Molecules. 2022 Nov 18; 27(22):8003. doi: 10.3390/molecules27228003" |
