| Title: | "One if by land, two if by sea: signalling to the ranks with CSP and XIP" |
| Address: | "Center for Pharmaceutical Biotechnology, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, IL 60607, USA. mjfederle@gmail.com" |
| ISSN/ISBN: | 1365-2958 (Electronic) 0950-382X (Print) 0950-382X (Linking) |
| Abstract: | "In many streptococci, quorum sensing utilizes secreted, linear peptides that engage cognate receptors to coordinate gene expression among members of a local population. Streptococcus mutans employs the secreted peptides CSP and XIP to stimulate production of antimicrobial bacteriocins and to induce development of competence for genetic transformation. Recent progress in the field reveals that these pathways not only monitor the presence of signal emitters but also sense environmental factors. Both kinds of information are integrated by regulatory networks that then generate multiple outcomes, even among parallel cells growing in identical conditions. In this issue of Molecular Microbiology, Son and co-workers investigate how two medium types shape cellular responses to CSP and XIP pheromones in individuals across a population. Their findings characterize restrictive properties of media differing in peptidic fragment content and reveal unusual signalling properties that contribute to bimodal responses of gene expression" |
| Keywords: | "Bacterial Proteins/genetics/metabolism Gene Expression Regulation, Bacterial Peptides/*metabolism Quorum Sensing *Signal Transduction Streptococcus mutans/genetics/*metabolism;" |
| Notes: | "MedlineFederle, Michael J Morrison, Donald A eng R01 AI091779/AI/NIAID NIH HHS/ R03 AI128228/AI/NIAID NIH HHS/ AI091779/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. England 2012/09/11 Mol Microbiol. 2012 Oct; 86(2):241-5. doi: 10.1111/mmi.12029. Epub 2012 Sep 19" |
