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Int J Environ Res Public Health

Title:		Urinary Biomarkers of Exposure to Volatile Organic Compounds from the Population Assessment of Tobacco and Health Study Wave 1 (2013-2014)
Author(s):		De Jesus VR; Bhandari D; Zhang L; Reese C; Capella K; Tevis D; Zhu W; Del Valle-Pinero AY; Lagaud G; Chang JT; van Bemmel D; Kimmel HL; Sharma E; Goniewicz ML; Hyland A; Blount BC;
Address:		"Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA. Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA. National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA. Westat, 1600 Research Boulevard, Rockville, MD 20850, USA. Division of Cancer Prevention and Population Sciences, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA"
Journal Title:		Int J Environ Res Public Health
Year:		2020
Volume:		20200728
Issue:		15
Page Number:		-
DOI:		10.3390/ijerph17155408
ISSN/ISBN:		1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking)
Abstract:		"Volatile organic compounds (VOCs) are ubiquitous in the environment. In the United States (U.S.), tobacco smoke is the major non-occupational source of exposure to many harmful VOCs. Exposure to VOCs can be assessed by measuring their urinary metabolites (VOCMs). The Population Assessment of Tobacco and Health (PATH) Study is a U.S. national longitudinal study of tobacco use in the adult and youth civilian non-institutionalized population. We measured 20 VOCMs in urine specimens from a subsample of adults in Wave 1 (W1) (2013-2014) to characterize VOC exposures among tobacco product users and non-users. We calculated weighted geometric means (GMs) and percentiles of each VOCM for exclusive combustible product users (smokers), exclusive electronic cigarette (e-cigarette) users, exclusive smokeless product users, and tobacco product never users. We produced linear regression models for six VOCMs with sex, age, race, and tobacco user group as predictor variables. Creatinine-ratioed levels of VOCMs from exposure to acrolein, crotonaldehyde, isoprene, acrylonitrile, and 1,3-butadiene were significantly higher in smokers than in never users. Small differences of VOCM levels among exclusive e-cigarette users and smokeless users were observed when compared to never users. Smokers showed higher VOCM concentrations than e-cigarette, smokeless, and never users. Urinary VOC metabolites are useful biomarkers of exposure to harmful VOCs"
Keywords:		Adolescent Adult Biomarkers/urine *Electronic Nicotine Delivery Systems Humans Longitudinal Studies Male Tobacco *Tobacco Products United States/epidemiology *Volatile Organic Compounds PATH Study e-cigarette users smokeless tobacco users tobacco smoke ex;
Notes:		"MedlineDe Jesus, Victor R Bhandari, Deepak Zhang, Luyu Reese, Christopher Capella, Kimberly Tevis, Denise Zhu, Wanzhe Del Valle-Pinero, Arseima Y Lagaud, Guy Chang, Joanne T van Bemmel, Dana Kimmel, Heather L Sharma, Eva Goniewicz, Maciej L Hyland, Andrew Blount, Benjamin C eng HHSN271201100027C/DA/NIDA NIH HHS/ HHSN271201600001C/DA/NIDA NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Switzerland 2020/08/01 Int J Environ Res Public Health. 2020 Jul 28; 17(15):5408. doi: 10.3390/ijerph17155408"