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Antibiotics (Basel)

Title:		"Pharmacological Properties, Volatile Organic Compounds, and Genome Sequences of Bacterial Endophytes from the Mangrove Plant Rhizophora apiculata Blume"
Author(s):		Dat TTH; Oanh PTT; Cuong LCV; Anh LT; Minh LTH; Ha H; Lam LT; Cuong PV; Anh HLT;
Address:		"Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, 321 Huynh Thuc Khang, Hue City 49117, Vietnam. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Vietnam. Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Vietnam. Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Vietnam"
Journal Title:		Antibiotics (Basel)
Year:		2021
Volume:		20211205
Issue:		12
Page Number:		-
DOI:		10.3390/antibiotics10121491
ISSN/ISBN:		2079-6382 (Print) 2079-6382 (Electronic) 2079-6382 (Linking)
Abstract:		"Mangrove plant endophytic bacteria are prolific sources of bioactive secondary metabolites. In the present study, twenty-three endophytic bacteria were isolated from the fresh roots of the mangrove plant Rhizophora apiculata. The identification of isolates by 16S rRNA gene sequences revealed that the isolated endophytic bacteria belonged to nine genera, including Streptomyces, Bacillus, Pseudovibrio, Microbacterium, Brevibacterium, Microbulbifer, Micrococcus, Rossellomorea, and Paracoccus. The ethyl acetate extracts of the endophytic bacteria's pharmacological properties were evaluated in vitro, including antimicrobial, antioxidant, alpha-amylase and alpha-glucosidase inhibitory, xanthine oxidase inhibitory, and cytotoxic activities. Gas chromatography-mass spectrometry (GC-MS) analyses of three high bioactive strains Bacillus sp. RAR_GA_16, Rossellomorea vietnamensis RAR_WA_32, and Bacillus sp. RAR_M1_44 identified major volatile organic compounds (VOCs) in their ethyl acetate extracts. Genome analyses identified biosynthesis gene clusters (BGCs) of secondary metabolites of the bacterial endophytes. The obtained results reveal that the endophytic bacteria from R. apiculata may be a potential source of pharmacological secondary metabolites, and further investigations of the high bioactive strains-such as fermentation and isolation of pure bioactive compounds, and heterologous expression of novel BGCs in appropriate expression hosts-may allow exploring and exploiting the promising bioactive compounds for future drug development"
Keywords:		Gc-ms Rhizophora apiculata biological activity biosynthesis gene clusters endophytic bacteria genome;
Notes:		"PubMed-not-MEDLINEDat, Ton That Huu Oanh, Phung Thi Thuy Cuong, Le Canh Viet Anh, Le Tuan Minh, Le Thi Hong Ha, Hoang Lam, Le Tung Cuong, Pham Viet Anh, Hoang Le Tuan eng DL0000.02/19-20/Vietnam Academy of Science and Technology/ Switzerland 2021/12/25 Antibiotics (Basel). 2021 Dec 5; 10(12):1491. doi: 10.3390/antibiotics10121491"