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Curr Med Chem

Title:		"Terpenes, Phenylpropanoids, Sulfur and Other Essential Oil Constituents as Inhibitors of Cholinesterases"
Author(s):		Burcul F; Blazevic I; Radan M; Politeo O;
Address:		"Department of Biochemistry, Faculty of Chemistry and Technology, University of Split, Split, Croatia. Department of Organic Chemistry, Faculty of Chemistry and Technology, University of Split, Split, Croatia"
Journal Title:		Curr Med Chem
Year:		2020
Volume:		27
Issue:		26
Page Number:		4297 - 4343
DOI:		10.2174/0929867325666180330092607
ISSN/ISBN:		1875-533X (Electronic) 0929-8673 (Linking)
Abstract:		"Essential oils constituents are a diverse family of low molecular weight organic compounds with comprehensive biological activity. According to their chemical structure, these active compounds can be divided into four major groups: terpenes, terpenoids, phenylpropenes, and 'others'. In addition, they may contain diverse functional groups according to which they can be classified as hydrocarbons (monoterpenes, sesquiterpenes, and aliphatic hydrocarbons); oxygenated compounds (monoterpene and sesquiterpene alcohols, aldehydes, ketones, esters, and other oxygenated compounds); and sulfur and/or nitrogen containing compounds (thioesters, sulfides, isothiocyanates, nitriles, and others). Compounds that act as cholinesterase inhibitors still represent the only pharmacological treatment of Alzheimer s disease. Numerous in vitro studies showed that some compounds, found in essential oils, have a promising cholinesterase inhibitory activity, such as alpha-pinene, delta-3-carene, 1,8-cineole, carvacrol, thymohydroquinone, alpha- and beta-asarone, anethole, etc. This review summarizes the most relevant research published to date on essential oil constituents and their acetylcholinesterase/butyrylcholinesterase inhibitory potential as well as their structure related activity, synergistic and antagonistic effects"
Keywords:		"Acetylcholinesterase Cholinesterase Inhibitors/*pharmacology Oils, Volatile Sulfur Terpenes butyrylcholinesterase phenylpropanoids structureactivity relationship sulfur volatiles synergism;"
Notes:		"MedlineBurcul, Franko Blazevic, Ivica Radan, Mila Politeo, Olivera eng Review United Arab Emirates 2018/03/31 Curr Med Chem. 2020; 27(26):4297-4343. doi: 10.2174/0929867325666180330092607"