| Title: | Sniffing a human sex-steroid derived compound affects mood and autonomic arousal in a dose-dependent manner |
| Author(s): | Bensafi M; Tsutsui T; Khan R; Levenson RW; Sobel N; |
| Address: | "Helen Wills Neuroscience Institute, 3210 Tolman Hall MC 1650, University of California at Berkeley, Berkeley, CA 94720, USA. bensafi@uclink.berkeley.edu" |
| DOI: | 10.1016/j.psyneuen.2004.03.007 |
| ISSN/ISBN: | 0306-4530 (Print) 0306-4530 (Linking) |
| Abstract: | "The effects of sniffing different concentrations of the human sex-steroid derived compound 4,16-androstadien-3-one (AND) on autonomic nervous system function and mood were measured in 60 subjects. The effects were sex-specific and concentration-dependent. Only high concentrations of AND (0.00625 M) increased positive mood (p < 0.03) and decreased negative mood (p < 0.05) in women compared to men, and had sympathetic-like effects in women (p < 0.003), and parasympathetic-like effects in men (p < 0.05). These findings further implicate AND in chemical communication between humans, but pose questions as to the path by which AND is transduced, whether through chemical sensing or transdermal diffusion" |
| Keywords: | "Administration, Intranasal Adolescent Adult Affect/*drug effects/physiology Analysis of Variance Androstadienes/*administration & dosage Arousal/*drug effects/physiology Autonomic Nervous System/*drug effects/physiology Dose-Response Relationship, Drug Fe;Neuroscience;" |
| Notes: | "MedlineBensafi, M Tsutsui, T Khan, R Levenson, R W Sobel, N eng Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't England 2004/08/04 Psychoneuroendocrinology. 2004 Nov; 29(10):1290-9. doi: 10.1016/j.psyneuen.2004.03.007" |
