| Title: | Evaluation of Approach to a Conspecific and Blood Biochemical Parameters in TAAR1 Knockout Mice |
| Author(s): | Zhukov IS; Ptukha MA; Zolotoverkhaja EA; Sinitca EL; Tissen IY; Karpova IV; Volnova AB; Gainetdinov RR; |
| Address: | "Institute of Translational Biomedicine, Saint Petersburg State University, Universitetskaya Nab., 7-9, 199034 Saint Petersburg, Russia. S. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Federal State Budgetary Scientific Institution, Academica Pavlova Str. 12, 197376 Saint Petersburg, Russia. Laboratory of Biochemical Toxicology and Pharmacology, Golikov Research Center of Toxicology, Federal Medical-Biological Agency, Bekhtereva Str. 1, 192019 Saint Petersburg, Russia. Saint Petersburg State University Hospital, Saint Petersburg State University, Universitetskaya Nab., 7-9, 199034 Saint Petersburg, Russia" |
| ISSN/ISBN: | 2076-3425 (Print) 2076-3425 (Electronic) 2076-3425 (Linking) |
| Abstract: | "It is known that the trace amine-associated receptor 1 (TAAR1) receptor is involved in limbic brain functions by regulating dopamine transmission and putative reward circuitry. Moreover, other TAARs are expressed in the olfactory system of all studied vertebrate species, sensing innate socially-relevant odors, including pheromones. Therefore, one can assume that TAARs may play a role in rodent social and sexual behavior. A comparative behavioral and biochemical analysis of TAAR1 knockout (TAAR1-KO) and wild-type mice is also important for the preliminary evaluation of the potential side effects of future TAAR1-based therapies. In our studies, we adapted a sexual incentive motivation test for mice to evaluate the sexual behavior of TAAR1-KO and wild-type mice. Previously, similar methods were primarily applied to rats. Furthermore, we measured testosterone and other biochemical parameters in the blood. As a result, we found only minimal alterations in all of the studied parameters. Thus, the lack of TAAR1 does not significantly affect sexual motivation and routine lipid and metabolic blood biochemical parameters, suggesting that future TAAR1-based therapies should have a favorable safety profile" |
| Keywords: | Taar Taar1 biochemistry mice sexual motivation safety profile testosterone trace amines; |
| Notes: | "PubMed-not-MEDLINEZhukov, Ilya S Ptukha, Maria A Zolotoverkhaja, Ekaterina A Sinitca, Ekaterina L Tissen, Ilya Y Karpova, Inessa V Volnova, Anna B Gainetdinov, Raul R eng 19-75-30008/Russian Science Foundation/ Switzerland 2022/05/29 Brain Sci. 2022 May 8; 12(5):614. doi: 10.3390/brainsci12050614" |
