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Genome Biol Evol

Title:		Expressed Vomeronasal Type-1 Receptors (V1rs) in Bats Uncover Conserved Sequences Underlying Social Chemical Signaling
Author(s):		Yohe LR; Davies KTJ; Rossiter SJ; Davalos LM;
Address:		"Department of Ecology and Evolution, Stony Brook University, NY. Department of Geology & Geophysics, Yale University, New Haven, CT. School of Biological and Chemical Sciences, Queen Mary University of London, United Kingdom. Consortium for Inter-Disciplinary Environmental Research, Stony Brook University, Stony Brook, NY"
Journal Title:		Genome Biol Evol
Year:		2019
Volume:		11
Issue:		10
Page Number:		2741 - 2749
DOI:		10.1093/gbe/evz179
ISSN/ISBN:		1759-6653 (Electronic) 1759-6653 (Linking)
Abstract:		"In mammals, social and reproductive behaviors are mediated by chemical cues encoded by hyperdiverse families of receptors expressed in the vomeronasal organ. Between species, the number of intact receptors can vary by orders of magnitude. However, the evolutionary processes behind variation in receptor number, and its link to fitness-related behaviors are not well understood. From vomeronasal transcriptomes, we discovered the first evidence of intact vomeronasal type-1 receptor (V1r) genes in bats, and we tested whether putatively functional bat receptors were orthologous to those of related taxa, or whether bats have evolved novel receptors. Instead of lineage-specific duplications, we found that bat V1rs show high levels of orthology to those of their relatives, and receptors are under comparative levels of purifying selection as non-bats. Despite widespread vomeronasal organ loss in bats, V1r copies have been retained for >65 million years. The highly conserved nature of bat V1rs challenges our current understanding of mammalian V1r function and suggests roles other than conspecific recognition or mating initiation in social behavior"
Keywords:		"Animal Communication Animals Base Sequence Chiroptera/genetics/*metabolism Conserved Sequence Evolution, Molecular Phylogeny Receptors, Pheromone/genetics/*metabolism Vomeronasal Organ/*metabolism V1r Chiroptera chemosensation gene tree pheromone vomerona;"
Notes:		"MedlineYohe, Laurel R Davies, Kalina T J Rossiter, Stephen J Davalos, Liliana M eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England 2019/08/20 Genome Biol Evol. 2019 Oct 1; 11(10):2741-2749. doi: 10.1093/gbe/evz179"