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Clin Med Insights Oncol

Title:		Diagnostic Ability of Volatile Organic Compounds in Digestive Cancer: A Systematic Review With Meta-Analysis
Author(s):		Yang H; Mou Y; Hu B;
Address:		"Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China"
Journal Title:		Clin Med Insights Oncol
Year:		2022
Volume:		20220620
Issue:
Page Number:		1.17955E+16 -
DOI:		10.1177/11795549221105027
ISSN/ISBN:		1179-5549 (Print) 1179-5549 (Electronic) 1179-5549 (Linking)
Abstract:		"BACKGROUND: Volatile organic compounds (VOCs) have been involved in cancer diagnosis via breath, urine, and feces. We aimed to assess the diagnostic ability of VOCs on digestive cancers. METHODS: We systematically reviewed prospective clinical trials evaluating VOCs' diagnostic ability on esophageal, gastric, colorectal, hepatic, and pancreatic cancer (PC). Databases including PubMed and Ovid-Medline were searched. RESULTS: A total of 35 trials with 5314 patient-times qualified for inclusion. The pooled sensitivity of VOCs diagnosing gastroesophageal cancer from healthy controls is 0.89 (95% confidence interval [CI]: 0.82-0.94), the pooled specificity is 0.890 (95% CI: 0.84-0.93), and area under the curve (AUC) of the summary receiver operating characteristic curve is 0.95 (95% CI: 0.93-0.95). The pooled sensitivity of VOCs diagnosing colorectal cancer from heathy controls is 0.92 (95% CI: 0.85-0.96), the pooled specificity is 0.88 (95% CI: 0.77-0.94), and the AUC is 0.96 (95% CI: 0.94-0.97). The pooled sensitivity of VOCs distinguishing gastrointestinal (GI) cancer from precancerous lesions is 0.84 (95% CI: 0.67-0.92), the pooled specificity is 0.74 (95% CI: 0.43-0.91), and the AUC is 0.87 (95% CI: 0.84-0.89). The pooled sensitivity of VOCs diagnosing hepatocellular carcinoma is 0.68 (95% CI: 0.52-0.81), the pooled specificity is 0.81 (95% CI: 0.47-0.96), and the AUC is 0.78 (95% CI: 0.74-0.81). The pooled sensitivity of VOCs diagnosing PC is 0.88 (95% CI: 0.80-0.93), the pooled specificity is 0.82 (95% CI: 0.62-0.93), and the AUC is 0.92 (95% CI: 0.89-0.94). CONCLUSIONS: Volatile organic compounds have potential role in diagnosing GI cancer with comparatively high sensitivity, specificity, and AUC (PROSPERO registration number: CRD42021260039)"
Keywords:		Volatile organic compounds diagnosis digestive cancer gas biopsy meta-analysis;
Notes:		"PubMed-not-MEDLINEYang, Hang Mou, Yi Hu, Bing eng 2022/06/28 Clin Med Insights Oncol. 2022 Jun 20; 16:11795549221105027. doi: 10.1177/11795549221105027. eCollection 2022"