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Sci Adv

Title:		Highly sensitive VOC detectors using insect olfactory receptors reconstituted into lipid bilayers
Author(s):		Yamada T; Sugiura H; Mimura H; Kamiya K; Osaki T; Takeuchi S;
Address:		"Artificial Cell Membrane Systems Group, Kanagawa Institute of Industrial Science and Technology, 3-2-1 Sakado, Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan. Division of Molecular Science, Graduate School of Science and Technology Gunma University, 1-5-1 Tenjin-cho, Kiryu city, Gunma 376-8515, Japan. Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan. Artificial Cell Membrane Systems Group, Kanagawa Institute of Industrial Science and Technology, 3-2-1 Sakado, Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan. takeuchi@hybrid.t.u-tokyo.ac.jp. Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"
Journal Title:		Sci Adv
Year:		2021
Volume:		20210113
Issue:		3
Page Number:		-
DOI:		10.1126/sciadv.abd2013
ISSN/ISBN:		2375-2548 (Electronic) 2375-2548 (Linking)
Abstract:		"This paper reports a volatile organic compound (VOC) sensor based on olfactory receptors that were reconstituted into a lipid bilayer and used in a specifically designed gas flow system for rapid parts per billion (ppb)-level detection. This VOC sensor achieves both rapid detection and high detection probability because of its gas flow system and array design. Specifically, the gas flow system includes microchannels and hydrophobic microslits, which facilitate both the introduction of gas into the droplet and droplet mixing. We installed this system into a parallel lipid bilayer device and subsequently demonstrated parts per billion-level (0.5 ppb) detection of 1-octen-3-ol in human breath. Therefore, this system extends the various applications of biological odorant sensing, including breath diagnosis systems and environmental monitoring"
Keywords:
Notes:		"PubMed-not-MEDLINEYamada, Tetsuya Sugiura, Hirotaka Mimura, Hisatoshi Kamiya, Koki Osaki, Toshihisa Takeuchi, Shoji eng Research Support, Non-U.S. Gov't 2021/02/02 Sci Adv. 2021 Jan 13; 7(3):eabd2013. doi: 10.1126/sciadv.abd2013. Print 2021 Jan"