| Title: | Inductive and synergistic interactions between plant allelochemical flavone and Bt toxin Cry1Ac in Helicoverpa armigera |
| Author(s): | Wang S; Zhang M; Huang J; Li L; Huang K; Zhang Y; Li Y; Deng Z; Ni X; Li X; |
| Address: | "School of Agricultural Sciences, Zhengzhou University, Zhengzhou, China. School of Life Sciences, Zhengzhou University, Zhengzhou, China. USDA-ARS, Crop Genetics and Breeding Research Unit, University of Georgia-Tifton Campus, Tifton, GA, USA. Department of Entomology and BIO5 Institute, University of Arizona, Tucson, AZ, USA" |
| ISSN/ISBN: | 1744-7917 (Electronic) 1672-9609 (Linking) |
| Abstract: | "Genetically engineered crops simultaneously produce defensive allelochemicals and Bacillus thuringiensis (Bt) toxin proteins to kill some of the world's most devastating insect pests. How the two types of toxins, when ingested sequentially or simultaneously, interact at both lethal and sublethal doses in these pests remains underexplored. Here, we examined the toxicological interactions between the Bt toxin Cry1Ac and the flavonoid allelochemical flavone in Helicoverpa armigera. Simultaneous exposure of H. armigera neonates to lethal doses (LC(25) ) of Cry1Ac and flavone caused a mortality significantly higher than that of either toxin alone and their expected additive mortality. Preexposure for 24 h to a sublethal dose (LC(10) ) of Cry1Ac followed by 6-d simultaneous exposure to the same dose of Cry1Ac plus a lethal dose (1.6 mg/g diets, LC(50) ) of flavone resulted in a mortality significantly higher than that of the LC(50) dose of flavone alone and the expected additive mortality of the LC(50) dose of flavone plus the LC(10) dose of Cry1Ac. One-day preexposure to the sublethal dose (LC(10) ) of flavone followed by 6-d simultaneous exposure to the LC(50) dose (6 ng/cm(2) ) of Cry1Ac plus the LC(10) dose of flavone yielded a mortality significantly higher than that of the LC(50) dose of Cry1Ac but similar to the expected additive mortality of the LC(50) dose of Cry1Ac plus the LC(10) dose of flavone. The results suggest that Cry1Ac induces and synergizes the toxicity of flavone against H. armigera larvae" |
| Keywords: | Animals Bacillus thuringiensis Toxins/*toxicity *Flavones/toxicity *Insect Control Larva *Moths *Pheromones/toxicity Bt crops allelochemicals combination toxicity induced toxicity resistance toxicological interactions; |
| Notes: | "MedlineWang, Shan Zhang, Min Huang, Jinyong Li, Leyao Huang, Kaiyuan Zhang, Yuting Li, Yalu Deng, Zhongyuan Ni, Xinzhi Li, Xianchun eng 21A210027/Key Scientific Research Projects of Colleges and Universities in Henan Province/ ARZT-1370680-R31-172/USDA National Institute of Food and Agriculture Hatch Project/ CB2020A06/State Key Laboratory of Cotton Biology/ U2004206/National Science Foundation of China (NSFC)-Henan Joint major grant/ Australia 2020/12/31 Insect Sci. 2021 Dec; 28(6):1756-1765. doi: 10.1111/1744-7917.12897. Epub 2020 Dec 29" |
