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Sci Total Environ

Title:		Association of urinary dimethylformamide metabolite with lung function decline: The potential mediating role of systematic inflammation estimated by C-reactive protein
Author(s):		Wang B; Yang S; Guo Y; Wan Y; Qiu W; Cheng M; Wang X; Yang M; Yu Y; Ma J; Zhou Y; Li W; Gan S; Shi T; Yuan J; Chen W;
Address:		"Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Institute of Environmental Health, Wuhan Centers for Disease Prevention & Control, Wuhan, Hubei 430015, China. School of Chemistry & Environment, South China Normal University, Guangzhou, Guangdong 510006, China. Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China. Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: wchen@mails.tjmu.edu.cn"
Journal Title:		Sci Total Environ
Year:		2020
Volume:		20200410
Issue:
Page Number:		138604 -
DOI:		10.1016/j.scitotenv.2020.138604
ISSN/ISBN:		1879-1026 (Electronic) 0048-9697 (Linking)
Abstract:		"Dimethylformamide (DMF) is a volatile organic compound listed as one of the four toxicants with the highest priority for human field study. However, the effect of DMF exposure on lung function and the underlying mechanisms remain unknown. We aimed to investigate the exposure-response relationship and possible mechanism between internal DMF exposure and lung function alteration. We studied 3701 Chinese adults from the Wuhan-Zhuhai cohort with a 3-year follow-up. The cross-sectional relationship between urinary biomarker of DMF exposure (N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine, AMCC) and lung function, and the mediating role of plasma C-reactive protein (CRP) were assessed. We also convened a sub-cohort (N = 138) to assess the stability of AMCC in repeated urine samples collected for continuous 3 days and intervals of 1, 2 and 3 years. The longitudinal association between AMCC and lung function change in 3 years was further assessed. We found a dose-response relationship between AMCC and lung function reduction. Each 2-fold increase in AMCC was cross-sectionally associated with a 23.12-mL (95% CI: -36.68, -9.55) decrease in FVC and a 19.01-mL (95% CI: -31.08, -6.93) decrease in FEV(1). Increased CRP significantly mediated 5.39% and 5.87% of the AMCC-associated FVC and FEV(1) reductions, respectively. With 3-year follow-up, AMCC showed a fair to excellent stability (intra-class correlation coefficients were 0.88, 0.55, 0.60 and 0.50 for continuous 3 days, intervals of 1, 2 and 3 years, respectively) and was dose-dependently associated with longitudinal lung function decline. Compared with those with persistent low AMCC levels, participants with persistent high AMCC levels had a 101.09-mL/year (95% CI: -167.40, -34.77) decline in FVC and a 66.27-mL/year (95% CI: -114.14, -18.41) decline in FEV(1) in the sub-cohort. Similar results were found in the full-cohort. Our findings suggest that exposure of general population to environmental DMF may impair lung function, and systematic inflammation may be an underlying mechanism"
Keywords:		Acetylcysteine Adult C-Reactive Protein Cross-Sectional Studies *Dimethylformamide Formamides Humans Inflammation Lung *Occupational Exposure Dimethylformamide Lung function Mechanism Mediation analysis;
Notes:		"MedlineWang, Bin Yang, Shijie Guo, Yanjun Wan, Yanjian Qiu, Weihong Cheng, Man Wang, Xing Yang, Meng Yu, Yan Ma, Jixuan Zhou, Yun Li, Wei Gan, Shiming Shi, Tingming Yuan, Jing Chen, Weihong eng Netherlands 2020/04/20 Sci Total Environ. 2020 Jul 15; 726:138604. doi: 10.1016/j.scitotenv.2020.138604. Epub 2020 Apr 10"