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Cell

Title:		Generating parallel representations of position and identity in the olfactory system
Author(s):		Taisz I; Dona E; Munch D; Bailey SN; Morris BJ; Meechan KI; Stevens KM; Varela-Martinez I; Gkantia M; Schlegel P; Ribeiro C; Jefferis G; Galili DS;
Address:		"Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK. Champalimaud Foundation, Lisbon, Portugal. Department of Zoology, University of Cambridge, Cambridge, UK. Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK; Department of Zoology, University of Cambridge, Cambridge, UK. Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK; Department of Zoology, University of Cambridge, Cambridge, UK. Electronic address: jefferis@mrc-lmb.cam.ac.uk. Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK. Electronic address: dgalili@mrc-lmb.cam.ac.uk"
Journal Title:		Cell
Year:		2023
Volume:		20230525
Issue:		12
Page Number:		2556 - 2573
DOI:		10.1016/j.cell.2023.04.038
ISSN/ISBN:		1097-4172 (Electronic) 0092-8674 (Print) 0092-8674 (Linking)
Abstract:		"In Drosophila, a dedicated olfactory channel senses a male pheromone, cis-vaccenyl acetate (cVA), promoting female courtship while repelling males. Here, we show that separate cVA-processing streams extract qualitative and positional information. cVA sensory neurons respond to concentration differences in a 5-mm range around a male. Second-order projection neurons encode the angular position of a male by detecting inter-antennal differences in cVA concentration, which are amplified through contralateral inhibition. At the third circuit layer, we identify 47 cell types with diverse input-output connectivity. One population responds tonically to male flies, a second is tuned to olfactory looming, while a third integrates cVA and taste to coincidentally promote female mating. The separation of olfactory features resembles the mammalian what and where visual streams; together with multisensory integration, this enables behavioral responses appropriate to specific ethological contexts"
Keywords:		"Animals Female Male Drosophila melanogaster/metabolism *Drosophila Proteins/genetics/metabolism Sexual Behavior, Animal/physiology *Receptors, Odorant/metabolism Pheromones/metabolism Smell/physiology Drosophila/metabolism Mammals/metabolism connectomics;"
Notes:		"MedlineTaisz, Istvan Dona, Erika Munch, Daniel Bailey, Shanice N Morris, Billy J Meechan, Kimberly I Stevens, Katie M Varela-Martinez, Irene Gkantia, Marina Schlegel, Philipp Ribeiro, Carlos Jefferis, Gregory S X E Galili, Dana S eng WT_/Wellcome Trust/United Kingdom 2023/05/27 Cell. 2023 Jun 8; 186(12):2556-2573.e22. doi: 10.1016/j.cell.2023.04.038. Epub 2023 May 25"