« Previous AbstractCharacterization of an enantioselective odorant receptor in the yellow fever mosquito Aedes aegypti    Next AbstractThe Emergence of Insect Odorant Receptor-Based Biosensors »

Med Vet Entomol

Title:		Multiple activities of insect repellents on odorant receptors in mosquitoes
Author(s):		Bohbot JD; Fu L; Le TC; Chauhan KR; Cantrell CL; Dickens JC;
Address:		"Invasive Insect Biocontrol and Behavior Laboratory, Plant Sciences Institute, U.S. Department of Agriculture-Agricultural Research Service (USDA-ARS), Henry A. Wallace Beltsville Agricultural Research Center, Beltsville, MD, U.S.A. joseph.dickens@ars.usda.gov"
Journal Title:		Med Vet Entomol
Year:		2011
Volume:		20110314
Issue:		4
Page Number:		436 - 444
DOI:		10.1111/j.1365-2915.2011.00949.x
ISSN/ISBN:		1365-2915 (Electronic) 0269-283X (Linking)
Abstract:		"Several lines of evidence suggest that insect repellent molecules reduce mosquito-host contacts by interacting with odorants and odorant receptors (ORs), thereby ultimately affecting olfactory-driven behaviours. We describe the molecular effects of 10 insect repellents and a pyrethroid insecticide with known repellent activity on two highly specific Aedes aegypti (Diptera: Culicidae) ORs, AaOR2 + AaOR7 and AaOR8 + AaOR7, exquisitely sensitive to key mosquito attractants indole and (R)-(-)-1-octen-3-ol, expressed in oocytes of Xenopus (Anura: Pipidae). Our study demonstrates that insect repellents can both inhibit odorant-evoked currents mediated by ORs and independently elicit currents in the absence of odorants. All of the repellents had effects on one or both ORs; most of these compounds were selective inhibitors and showed a high degree of specificity in their capacity to activate the two ORs. These results show that a range of insect repellents belonging to structurally diverse chemical classes modulate the function of mosquito ORs through multiple molecular mechanisms"
Keywords:		"Aedes/drug effects/*metabolism Animals Evoked Potentials Female Indoles/*metabolism Insect Repellents/*pharmacology Octanols/*metabolism Oocytes/drug effects Pheromones/*metabolism Receptors, Odorant/agonists/*metabolism Smell Xenopus laevis/metabolism;"
Notes:		"MedlineBohbot, J D Fu, L LE, T C Chauhan, K R Cantrell, C L Dickens, J C eng Intramural NIH HHS/ Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, U.S. Gov't, Non-P.H.S. England 2011/03/15 Med Vet Entomol. 2011 Dec; 25(4):436-44. doi: 10.1111/j.1365-2915.2011.00949.x. Epub 2011 Mar 14"