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Hum Reprod Update

Title:		Indoor and outdoor air pollution and couple fecundability: a systematic review
Author(s):		Siegel EL; Ghassabian A; Hipwell AE; Factor-Litvak P; Zhu Y; Steinthal HG; Focella C; Battaglia L; Porucznik CA; Collingwood SC; Klein-Fedyshin M; Kahn LG;
Address:		"Columbia University, Mailman School of Public Health, New York, NY, USA. New York University Grossman School of Medicine, New York, NY, USA. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. New York University, School of Global Public Health, New York, NY, USA. University of Utah, School of Medicine, Salt Lake City, UT, USA. University of Pittsburgh, Health Sciences Library System, Pittsburgh, PA, USA"
Journal Title:		Hum Reprod Update
Year:		2023
Volume:		29
Issue:		1
Page Number:		45 - 70
DOI:		10.1093/humupd/dmac029
ISSN/ISBN:		1460-2369 (Electronic) 1355-4786 (Print) 1355-4786 (Linking)
Abstract:		"BACKGROUND: Air pollution is both a sensory blight and a threat to human health. Inhaled environmental pollutants can be naturally occurring or human-made, and include traffic-related air pollution (TRAP), ozone, particulate matter (PM) and volatile organic compounds, among other substances, including those from secondhand smoking. Studies of air pollution on reproductive and endocrine systems have reported associations of TRAP, secondhand smoke (SHS), organic solvents and biomass fueled-cooking with adverse birth outcomes. While some evidence suggests that air pollution contributes to infertility, the extant literature is mixed, and varying effects of pollutants have been reported. OBJECTIVE AND RATIONALE: Although some reviews have studied the association between common outdoor air pollutants and time to pregnancy (TTP), there are no comprehensive reviews that also include exposure to indoor inhaled pollutants, such as airborne occupational toxicants and SHS. The current systematic review summarizes the strength of evidence for associations of outdoor air pollution, SHS and indoor inhaled air pollution with couple fecundability and identifies gaps and limitations in the literature to inform policy decisions and future research. SEARCH METHODS: We performed an electronic search of six databases for original research articles in English published since 1990 on TTP or fecundability and a number of chemicals in the context of air pollution, inhalation and aerosolization. Standardized forms for screening, data extraction and study quality were developed using DistillerSR software and completed in duplicate. We used the Newcastle-Ottawa Scale to assess risk of bias and devised additional quality metrics based on specific methodological features of both air pollution and fecundability studies. OUTCOMES: The search returned 5200 articles, 4994 of which were excluded at the level of title and abstract screening. After full-text screening, 35 papers remained for data extraction and synthesis. An additional 3 papers were identified independently that fit criteria, and 5 papers involving multiple routes of exposure were removed, yielding 33 articles from 28 studies for analysis. There were 8 papers that examined outdoor air quality, while 6 papers examined SHS exposure and 19 papers examined indoor air quality. The results indicated an association between outdoor air pollution and reduced fecundability, including TRAP and specifically nitrogen oxides and PM with a diameter of
Keywords:		Pregnancy Female Humans *Air Pollution/adverse effects/analysis *Air Pollutants/adverse effects/analysis *Tobacco Smoke Pollution Particulate Matter/analysis Fertility *Environmental Pollutants air pollution fecundability fecundity formaldehyde infertilit;
Notes:		"MedlineSiegel, Eva L Ghassabian, Akhgar Hipwell, Alison E Factor-Litvak, Pam Zhu, Yeyi Steinthal, Hannah G Focella, Carolina Battaglia, Lindsey Porucznik, Christina A Collingwood, Scott C Klein-Fedyshin, Michele Kahn, Linda G eng UH3 OD023249/OD/NIH HHS/ U2C OD023375/OD/NIH HHS/ F31 ES032331/ES/NIEHS NIH HHS/ R01 HL157666/HL/NHLBI NIH HHS/ UG3 OD023305/OD/NIH HHS/ U24 OD023319/OD/NIH HHS/ K99 ES030403/ES/NIEHS NIH HHS/ UH3 OD023244/OD/NIH HHS/ R00 ES030403/ES/NIEHS NIH HHS/ U24 OD023382/OD/NIH HHS/ UH3 OD023289/OD/NIH HHS/ Research Support, N.I.H., Extramural Systematic Review England 2022/07/28 Hum Reprod Update. 2023 Jan 5; 29(1):45-70. doi: 10.1093/humupd/dmac029"