« Previous AbstractMutagenic atmospheres resulting from the photooxidation of aromatic hydrocarbon and NO(x) mixtures    Next AbstractAnalysis of volatile organic compounds: possible applications in metabolic disorders and cancer screening »

Clin Transl Gastroenterol

Title:		"A Distinct Colon-Derived Breath Metabolome is Associated with Inflammatory Bowel Disease, but not its Complications"
Author(s):		Rieder F; Kurada S; Grove D; Cikach F; Lopez R; Patel N; Singh A; Alkhouri N; Shen B; Brzezinski A; Baker M; Fiocchi C; Dweik RA;
Address:		"Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio, USA. Department of Pathobiology NC22, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA. Department of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA. Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA. Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA. Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio, USA. Imaging Institute, Cleveland Clinic, Cleveland, Ohio, USA"
Journal Title:		Clin Transl Gastroenterol
Year:		2016
Volume:		20161110
Issue:		11
Page Number:		e201 -
DOI:		10.1038/ctg.2016.57
ISSN/ISBN:		2155-384X (Print) 2155-384X (Electronic) 2155-384X (Linking)
Abstract:		"OBJECTIVES: The accuracy of available noninvasive biomarkers for diagnosis, stratification, and prediction of inflammatory bowel disease (IBD) courses is limited. We analyzed volatile organic compounds (VOCs) in the breath of IBD patients and controls for diagnosis and differentiation of IBD as well as their link with disease location, activity, and phenotype. METHODS: A prospective study of diagnostic testing was conducted, recruiting Crohn's disease (CD), ulcerative colitis (UC), other inflammatory gastrointestinal diseases (OGDs), and healthy controls (HCs), as well as subjects with ileal pouch anal anastomosis (IPAA). The breath VOC profile was analyzed using selective ion flow tube-mass spectrometry. RESULTS: One hundred and twenty-four subjects (n=24 CD, n=11 UC, n=6 OGD, n=53 HC, n=30 IPAA) were included. The breath metabolome was significantly different in patients with IBD, CD, or UC compared with OGD and HC (7 out of 22 VOCs), but not between CD and UC. No link between the level of VOCs with complications, disease location, and clinical or radiologic disease activity, as well as lab parameters or type of medication was found. Breath VOCs were markedly different in patients with IPAA compared with any other group (17 out of 22 VOCs) and the presence of pouch inflammation did not alter the VOC levels. CONCLUSIONS: A specific breath metabolome is associated with IBD and markedly changes in patients with IPAA. Analysis of a broader spectrum of VOCs can potentially aid in the development of breath prints to diagnose or differentiate inflammatory bowel disorders"
Keywords:
Notes:		"PubMed-not-MEDLINERieder, Florian Kurada, Satya Grove, David Cikach, Frank Lopez, Rocio Patel, Nishaben Singh, Amandeep Alkhouri, Naim Shen, Bo Brzezinski, Aaron Baker, Mark Fiocchi, Claudio Dweik, Raed A eng P30 DK097948/DK/NIDDK NIH HHS/ 2016/11/11 Clin Transl Gastroenterol. 2016 Nov 10; 7(11):e201. doi: 10.1038/ctg.2016.57"