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Res Nurs Health

Title:		Identifying phenotypes and factors impacting outcomes in older adults with asthma: A research protocol and recruitment results
Author(s):		Polivka BJ; Folz R; Myers J; Barnett R; Antimisiaris D; Jorayeva A; Beatty B;
Address:		"School of Nursing, University of Louisville, Louisville, Kentucky. Case Western Reserve University and University Hospital, Cleveland, Ohio. Department of Pediatrics, University of Louisville School, Louisville, Kentucky. University of Louisville, Louisville, Kentucky. Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky. Division of Pulmonary, Critical Care Medicine, and Sleep Disorders, University of Louisville, Louisville, Kentucky"
Journal Title:		Res Nurs Health
Year:		2018
Volume:		41
Issue:		4
Page Number:		336 - 345
DOI:		10.1002/nur.21880
ISSN/ISBN:		1098-240X (Electronic) 0160-6891 (Print) 0160-6891 (Linking)
Abstract:		"Success in testing research outcomes requires identification of effective recruitment strategies in the targeted population. In this paper, we present the protocol for our NIH-funded study as well as success rates for the various recruitment strategies employed. This longitudinal observational study is: developing a phenotyping algorithm for asthma in older adults, exploring the effects of the asthma phenotype and of volatile organic compounds on asthma control, and developing a predictive model of asthma quality of life. A sub-aim is to characterize barriers to successful medication management in older adults with asthma. Individuals are eligible if they are >/=60 years, have a positive response to at least 1 of 6 asthma screening questions, are non-smokers, and demonstrate bronchodilator reversibility or a positive bronchial challenge test with methacholine. Exclusion criteria are smokers who quit <5 years ago or with a >20 pack year smoking history, and those having other chronic pulmonary diseases. Participants (N = 190) complete baseline pulmonary function testing, questionnaires, sputum induction, skin prick testing, and have blood drawn for Vitamin D and Immunoglobulin E. Home environmental assessments are completed including 24-hr particulate and volatile organic compound measurements. At 9-months post-baseline, home spirometry, medication assessment, and assessment of asthma quality of life and asthma control are assessed. At 18-months post-baseline, home spirometry, completion of baseline questionnaires, and a home environmental assessment are completed. We have employed multiple recruitment efforts including referrals from clinical offices, no-cost media events, flyers, and ads. The most successful efforts have been referrals from clinical offices and media events"
Keywords:		Aged Asthma/*therapy Clinical Protocols Female Humans Longitudinal Studies Male *Phenotype *Quality of Life Treatment Outcome asthma environmental exposures longitudinal design older adults recruitment strategies;
Notes:		"MedlinePolivka, Barbara J Folz, Rodney Myers, John Barnett, Russell Antimisiaris, Demetra Jorayeva, Anna Beatty, Bryan eng R01 AG047297/AG/NIA NIH HHS/ R01AG047297/AG/NIA NIH HHS/ Observational Study Research Support, N.I.H., Extramural 2018/10/26 Res Nurs Health. 2018 Aug; 41(4):336-345. doi: 10.1002/nur.21880"