| Title: | Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells |
| Author(s): | Podlogar JA; Verspohl EJ; |
| Address: | "Department of Pharmacology, Institute of Medicinal Chemistry, Munster University, Hittorfstr. 58-62, 48149 Munster, Germany" |
| ISSN/ISBN: | 1099-1573 (Electronic) 0951-418X (Linking) |
| Abstract: | "The proinflammatory chemokine interleukin-8 is increased in asthmatic patients. Traditionally, ginger is used as an antiinflammatory drug. An extract and several compounds of Zingiber officinale (ginger) were tested in human bronchial epithelial cells (BEAS-2B cells) with respect to their effect on lipopolysaccharide (LPS)-induced secretion of the proinflammatory chemokine interleukin 8 (IL-8) and RANTES (regulated upon activation, normal T-cell expressed and secreted). An oily extract of ginger rhizome with > 25% total pungent compounds, ginger volatile oil, ar-curcumene and alpha-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and beta-phellandrene showed no effect. The LPS-induced slight increase of RANTES was reduced by volatile oil, ar-curcumene and alpha-pinene. There was no effect of LPS on TNF-alpha. Our results suggest that distinct ginger compounds could be used as antiinflammatory drugs in respiratory infections" |
| Keywords: | "Anti-Inflammatory Agents/chemistry/*pharmacology Bicyclic Monoterpenes Bronchi/*cytology/immunology Catechols/chemistry/pharmacology Cell Line Chemokine CCL5/immunology Cyclohexane Monoterpenes Cyclohexenes/chemistry Dose-Response Relationship, Immunologi;" |
| Notes: | "MedlinePodlogar, Julia A Verspohl, Eugen J eng England 2011/06/24 Phytother Res. 2012 Mar; 26(3):333-6. doi: 10.1002/ptr.3558. Epub 2011 Jun 23" |
