| Title: | Can oral health and oral-derived biospecimens predict progression of dementia? |
| Author(s): | Orr ME; Reveles KR; Yeh CK; Young EH; Han X; |
| Address: | "Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, Texas. Geriatric Research, Education & Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, Texas. Department of Medicine, UT Health San Antonio, San Antonio, Texas. Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, Texas. Gerontology and Geriatric Medicine, Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina. College of Pharmacy, The University of Texas at Austin, Austin, Texas. Pharmacotherapy Education & Research Center, UT Health San Antonio, San Antonio, Texas. Comprehensive Dentistry, School of Dentistry, UT Health San Antonio, San Antonio, Texas" |
| ISSN/ISBN: | 1601-0825 (Electronic) 1354-523X (Print) 1354-523X (Linking) |
| Abstract: | "Growing evidence indicates that oral health and brain health are interconnected. Declining cognition and dementia coincide with lack of self-preservation, including oral hygiene. The oral microbiota plays an important role in maintaining oral health. Emerging evidence suggests a link between oral dysbiosis and cognitive decline in patients with Alzheimer's disease. This review showcases the recent advances connecting oral health and cognitive function during aging and the potential utility of oral-derived biospecimens to inform on brain health. Collectively, experimental findings indicate that the connection between oral health and cognition cannot be underestimated; moreover, oral biospecimens are abundant and readily obtainable without invasive procedures, which may help inform on cognitive health" |
| Keywords: | Alzheimer Disease/diagnosis/physiopathology Cognition Cognitive Dysfunction/diagnosis/physiopathology Dementia/*diagnosis Disease Progression Humans *Microbiota Mouth/*microbiology *Oral Health Alzheimer's disease dementia oral health oral microbiome sali; |
| Notes: | "MedlineOrr, Miranda E Reveles, Kelly R Yeh, Chih-Ko Young, Eric H Han, Xianlin eng IK2 BX003804/BX/BLRD VA/ P30 AG044271/AG/NIA NIH HHS/ T32 AG021890/AG/NIA NIH HHS/ 1P30AG044271-01A1/National Institutes of Health/National Institute on Aging San Antonio Claude D. Pepper Older Americans Independence Center/ Review Denmark 2019/09/22 Oral Dis. 2020 Mar; 26(2):249-258. doi: 10.1111/odi.13201. Epub 2020 Jan 6" |
