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Genes Dev

Title:		The DAF-7 TGF-beta signaling pathway regulates chemosensory receptor gene expression in C. elegans
Author(s):		Nolan KM; Sarafi-Reinach TR; Horne JG; Saffer AM; Sengupta P;
Address:		"Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA"
Journal Title:		Genes Dev
Year:		2002
Volume:		16
Issue:		23
Page Number:		3061 - 3073
DOI:		10.1101/gad.1027702
ISSN/ISBN:		0890-9369 (Print) 0890-9369 (Linking)
Abstract:		"Regulation of chemoreceptor gene expression in response to environmental or developmental cues provides a mechanism by which animals can alter their sensory responses. Here we demonstrate a role for the daf-7 TGF-beta pathway in the regulation of expression of a subset of chemoreceptor genes in Caenorhabditis elegans. We describe a novel role of this pathway in maintaining receptor gene expression in the adult and show that the DAF-4 type II TGF-beta receptor functions cell-autonomously to modulate chemoreceptor expression. We also find that the alteration of receptor gene expression in the ASI chemosensory neurons by environmental signals, such as levels of a constitutively produced pheromone, may be mediated via a DAF-7-independent pathway. Receptor gene expression in the ASI and ASH sensory neurons appears to be regulated via distinct mechanisms. Our results suggest that the expression of individual chemoreceptor genes in C. elegans is subject to multiple modes of regulation, thereby ensuring that animals exhibit the responses most appropriate for their developmental stage and environmental conditions"
Keywords:		Animals Caenorhabditis elegans/genetics/physiology Caenorhabditis elegans Proteins/genetics/physiology Chemoreceptor Cells/*physiology DNA-Binding Proteins/genetics Gene Expression Regulation/genetics/*physiology Helminth Proteins/genetics/*physiology Mut;
Notes:		"MedlineNolan, Katherine M Sarafi-Reinach, Trina R Horne, Jennifer G Saffer, Adam M Sengupta, Piali eng F32 DC05310/DC/NIDCD NIH HHS/ R37 GM056223/GM/NIGMS NIH HHS/ GM56223/GM/NIGMS NIH HHS/ F32 DC005310/DC/NIDCD NIH HHS/ R01 GM056223/GM/NIGMS NIH HHS/ Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 2002/12/05 Genes Dev. 2002 Dec 1; 16(23):3061-73. doi: 10.1101/gad.1027702"