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Can J Physiol Pharmacol

Title:		gamma-Aminobutyric acid activity in the olfactory bulb of the rat during the sexual cycle and response to olfactory stimuli
Author(s):		Navarro Becerra N; Munaro NI;
Address:		"Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Argentina"
Journal Title:		Can J Physiol Pharmacol
Year:		1992
Volume:		70
Issue:		6
Page Number:		922 - 925
DOI:		10.1139/y92-124
ISSN/ISBN:		0008-4212 (Print) 0008-4212 (Linking)
Abstract:		"Glutamic acid decarboxylase activity in the main and accessory olfactory bulbs throughout the sexual cycle of the rat was studied. The effect of male pheromonal secretion on enzyme activity during proestrus and estrus day was also tested. The enzyme activity showed circadian rhythm during the estrous cycle. This rhythm was disrupted during diestrus-2 afternoon in the main bulb and came back during proestrus afternoon. A different pattern of enzyme activity was present in the accessory bulb, since the circadian rhythm was altered during proestrus morning, returning during estrus afternoon. Male odor exposition did not change enzyme profile activity during proestrus day and during estrus morning in the main bulb. In contrast, in the accessory bulb the olfactory stimuli induced opposite changes to that found in rats from the vivarium during proestrus. Comparison of enzyme activity in olfactory stimuli-deprived rats with that of pheromone-stimulated rats during proestrus showed that male odor exposure specifically affects accessory bulb enzyme activity. It is concluded that the changes of the olfactory bulb GABAergic system during proestrus and estrus day, or that evoked by odor stimuli, demonstrate the discriminative response of this system between the accessory olfactory bulb and the main olfactory bulb"
Keywords:		"Animals Circadian Rhythm/physiology Estrus/drug effects/metabolism/*physiology Female Glutamate Decarboxylase/metabolism Male Olfactory Bulb/drug effects/enzymology/*physiology Pheromones/pharmacology Proestrus/drug effects/metabolism Rats Rats, Wistar St;"
Notes:		"MedlineNavarro Becerra, N Munaro, N I eng Research Support, Non-U.S. Gov't Canada 1992/06/01 Can J Physiol Pharmacol. 1992 Jun; 70(6):922-5. doi: 10.1139/y92-124"