| Title: | A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans |
| Author(s): | Park D; Hahm JH; Park S; Ha G; Chang GE; Jeong H; Kim H; Kim S; Cheong E; Paik YK; |
| Address: | "Department of Biochemistry, Yonsei University, Seoul, Korea. Yonsei Proteome Research Center, Yonsei University, Seoul, Korea. Center for Plant Aging Research, Institute for Basic Science (IBS), Daegu, 42988, Republic of Korea. Department of Integrated Omics for Biomedical Science, Yonsei University, Seoul, Korea. Department of Biotechnology, and College of Life Science and Biotechnology, Yonsei University, Seoul, Korea. Department of Biochemistry, Yonsei University, Seoul, Korea. paikyk@yonsei.ac.kr. Yonsei Proteome Research Center, Yonsei University, Seoul, Korea. paikyk@yonsei.ac.kr. Department of Integrated Omics for Biomedical Science, Yonsei University, Seoul, Korea. paikyk@yonsei.ac.kr" |
| DOI: | 10.1038/s41598-017-07313-6 |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Animals use pheromones as a conspecific chemical language to respond appropriately to environmental changes. The soil nematode Caenorhabditis elegans secretes ascaroside pheromones throughout the lifecycle, which influences entry into dauer phase in early larvae, in addition to sexual attraction and aggregation. In adult hermaphrodites, pheromone sensory signals perceived by worms usually elicit repulsion as an initial behavioral signature. However, the molecular mechanisms underlying neuronal pheromone sensory process from perception to repulsion in adult hermaphrodites remain poorly understood. Here, we show that pheromone signals perceived by GPA-3 is conveyed through glutamatergic neurotransmission in which neuronal DAF-16/FoxO plays an important modulatory role by controlling glutaminase gene expression. We further provide evidence that this modulatory role for DAF-16/FoxO seems to be conserved evolutionarily by electro-physiological study in mouse primary hippocampal neurons that are responsible for glutamatergic neurotransmission. These findings provide the basis for understanding the nematode pheromone signaling, which seems crucial for adaptation of adult hermaphrodites to changes in environmental condition for survival" |
| Keywords: | "Animals Behavior, Animal Caenorhabditis elegans/*physiology Caenorhabditis elegans Proteins/*genetics/*metabolism Forkhead Transcription Factors/*genetics/*metabolism GTP-Binding Protein alpha Subunits, Gi-Go/genetics/metabolism Gene Expression Regulation;" |
| Notes: | "MedlinePark, Donha Hahm, Jeong-Hoon Park, Saeram Ha, Go Chang, Gyeong-Eon Jeong, Haelim Kim, Heekyeong Kim, Sunhee Cheong, Eunji Paik, Young-Ki eng P40 OD010440/OD/NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2017/08/05 Sci Rep. 2017 Aug 3; 7(1):7260. doi: 10.1038/s41598-017-07313-6" |
