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Environ Res

Title:		Exposure to Volatile Organic Compounds Is Associated with Hypertension in Black Adults: The Jackson Heart Study
Author(s):		McGraw KE; Konkle SL; Riggs DW; Rai SN; DeJarnett N; Xie Z; Keith RJ; Oshunbade A; Hall ME; Shimbo D; Bhatnagar A;
Address:		"Christina Lee Brown Envirome Institute, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA; University of Louisville Superfund Research Center, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA; University of Louisville School of Public Health and Information Sciences, 485 E Gray Street, Louisville, KY, 40202, USA. Christina Lee Brown Envirome Institute, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA. Christina Lee Brown Envirome Institute, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA; University of Louisville Superfund Research Center, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA. University of Mississippi Medical Center Department of Medicine - Cardiology, 2500 North State St, Jackson, MS, 39216, USA. Columbia University Department of Medicine, 161 Fort Washington Ave, New York, NY, USA. Christina Lee Brown Envirome Institute, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA; University of Louisville Superfund Research Center, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA. Electronic address: aruni@louisville.edu"
Journal Title:		Environ Res
Year:		2023
Volume:		20230214
Issue:
Page Number:		115384 -
DOI:		10.1016/j.envres.2023.115384
ISSN/ISBN:		1096-0953 (Electronic) 0013-9351 (Print) 0013-9351 (Linking)
Abstract:		"BACKGROUND: The prevalence of hypertension is higher among Black adults than among White and Hispanic adults. Nevertheless, reasons underlying the higher rates of hypertension in the Black population remain unclear but may relate to exposure to environmental chemicals such as volatile organic compounds (VOCs). METHODS: We evaluated the associations of blood pressure (BP) and hypertension with VOC exposure in non-smokers and smokers in a subgroup of the Jackson Heart Study (JHS), consisting of 778 never smokers and 416 age- and sex-matched current smokers. We measured urinary metabolites of 17 VOCs by mass spectrometry. RESULTS: After adjusting for covariates, we found that amoong non-smokers, metabolites of acrolein and crotonaldehyde were associated with a 1.6 mm Hg (95%CI: 0.4, 2.7; p = 0.007) and a 0.8 mm Hg (95%CI: 0.01, 1.6; p = 0.049) higher systolic BP, and the styrene metabolite was associated with a 0.4 mm Hg (95%CI: 0.09, 0.8, p = 0.02) higher diastolic BP. Current smokers had 2.8 mm Hg (95% CI 0.5, 5.1) higher systolic BP. They were at higher risk of hypertension (relative risk = 1.2; 95% CI, 1.1, 1.4), and had higher urinary levels of several VOC metabolites. Individuals who smoke had higher levels of the urinary metabolites of acrolein, 1,3-butadiene, and crotonaldehyde and were associated with higher systolic BP. The associations were stronger among participants who were <60 years of age and male. Using Bayesian kernel machine regression to assess the effects of multiple VOC exposures, we found that the relationship between VOCs and hypertension among non-smokers was driven primarily by acrolein and styrene in non-smokers, and crotonaldehyde in smokers. CONCLUSIONS: Hypertension in Black individuals may be attributed, in part, to VOC exposure from the environment or tobacco smoke"
Keywords:		Humans Adult Male *Volatile Organic Compounds/toxicity Acrolein Bayes Theorem Longitudinal Studies *Hypertension/chemically induced/epidemiology Styrenes Blood pressure Cardiovascular disease Cotinine Health disparities Multipollutant exposures Urinary me;
Notes:		"MedlineMcGraw, Katlyn E Konkle, Stacey L Riggs, Daniel W Rai, Shesh N DeJarnett, Natasha Xie, Zhengzhi Keith, Rachel J Oshunbade, Adebamike Hall, Michael E Shimbo, Diachi Bhatnagar, Aruni eng P42 ES023716/ES/NIEHS NIH HHS/ P50 HL120163/HL/NHLBI NIH HHS/ R01 ES029846/ES/NIEHS NIH HHS/ U54 HL120163/HL/NHLBI NIH HHS/ Research Support, N.I.H., Extramural Netherlands 2023/02/17 Environ Res. 2023 Apr 15; 223:115384. doi: 10.1016/j.envres.2023.115384. Epub 2023 Feb 14"