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Semin Thromb Hemost

Title:		E-cigarettes and cardiovascular risk: beyond science and mysticism
Author(s):		Lippi G; Favaloro EJ; Meschi T; Mattiuzzi C; Borghi L; Cervellin G;
Address:		"Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy. Department of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, New South Wales, Australia. Department of Clinical Sciences, University of Parma, Parma, Italy. Service of Clinical Governance, General Hospital of Trento, Trento, Italy. Emergency Department, Academic Hospital of Parma, Parma, Italy"
Journal Title:		Semin Thromb Hemost
Year:		2014
Volume:		20131216
Issue:		1
Page Number:		60 - 65
DOI:		10.1055/s-0033-1363468
ISSN/ISBN:		1098-9064 (Electronic) 0094-6176 (Linking)
Abstract:		"Cigarette smoking is the most important cause of premature death, and it is currently listed as a major independent risk factor for cardiovascular disease. Because of restrictive measures and widespread control policies, tobacco companies are now using aggressive marketing strategies in favor of smokeless tobacco, including electronic nicotine delivery systems, which are also known as electronic cigarettes or e-cigarettes. Although the regular use of these devices appears less hazardous than traditional cigarettes or other forms of smokeless tobacco, recent studies have shown that various potentially harmful substances, especially nicotine, ultraparticles, and volatile organic compounds, may be effectively inhaled or liberated in exhaled air during repeated e-cigarette puffing. This would enhance the risk of cardiac arrhythmias and hypertension, which may predispose some users to increased risk of cardiovascular events, which may be further magnified by other potential adverse effects such as arrhythmias, increased respiratory, and flow respiratory resistance. Some cases of intoxication have also been described, wherein large amounts of nicotine and other harmful compounds may be effectively absorbed. As the use of e-cigarettes is continuously rising, and it is also considered a potentially effective method for smoking cessation, more focused research is urgently needed to definitely establish the cardiovascular safeness of these devices"
Keywords:		"Administration, Inhalation *Arrhythmias, Cardiac/chemically induced/epidemiology/physiopathology Humans Nicotine/*adverse effects/pharmacology Nicotinic Agonists/*adverse effects/pharmacology Smoking Cessation Tobacco, Smokeless/adverse effects Volatile O;"
Notes:		"MedlineLippi, Giuseppe Favaloro, Emmanuel J Meschi, Tiziana Mattiuzzi, Camilla Borghi, Loris Cervellin, Gianfranco eng Review 2013/12/18 Semin Thromb Hemost. 2014 Feb; 40(1):60-5. doi: 10.1055/s-0033-1363468. Epub 2013 Dec 16"