| Title: | Influence of circadian rhythm on exhaled breath profiling by electronic nose |
| Author(s): | Liotino V; Dragonieri S; Quaranta VN; Carratu P; Ranieri T; Resta O; |
| Address: | "Respiratory Diseases, University of Bari, Italy. Pulmonology, Ospedale Di Venere, Bari, Italy" |
| Journal Title: | J Biol Regul Homeost Agents |
| ISSN/ISBN: | 0393-974X (Print) 0393-974X (Linking) |
| Abstract: | "Electronic noses (e-noses) are a cheap and easy method for exhaled Volatile Organic Compound (VOC)-analysis which has shown its potential in several diseases. Before obtaining a full validation of these instruments in clinical settings, a number of methodological issues still have to be established. We aimed to investigate a potential influence of circadian variation on VOC-profile analyzed by an e-nose in healthy subjects. We enrolled 22 adults free of any known diseases. A sequence of exhaled breath samplings were performed on all participants at predetermined hours (7am, 12pm, 17pm, 23pm) and analyzed by an e-nose (Cyranose 320). According to Principal Component Analysis, significant circadian variations of the exhaled VOC-profile were shown for Principal Component (PC) 1 and 3. In detail, PC1 and PC3 values were significantly higher in the morning compared to the afternoon and evening (for all parameters p less than 0.05). Successive Linear Discriminant analysis confirmed the findings above. The daily variations in VOCs-profile, with the peak in the morning, could be relevant for future clinical applications, especially in the choice of optimal time for sampling patients" |
| Keywords: | Adult *Breath Tests Circadian Rhythm/*physiology Discriminant Analysis *Electronic Nose Exhalation/*physiology Humans Linear Models Principal Component Analysis Time Factors Volatile Organic Compounds/analysis; |
| Notes: | "MedlineLiotino, V Dragonieri, S Quaranta, V N Carratu, P Ranieri, T Resta, O eng Letter Italy 2018/10/20 J Biol Regul Homeost Agents. 2018 Sep-Oct; 32(5):1261-1265" |
