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Nat Neurosci

Title:		Local inhibition modulates odor-evoked synchronization of glomerulus-specific output neurons
Author(s):		Lei H; Christensen TA; Hildebrand JG;
Address:		"Arizona Research Laboratories, Division of Neurobiology, University of Arizona, PO Box 210077, Tucson, Arizona 85721-0077, USA"
Journal Title:		Nat Neurosci
Year:		2002
Volume:		5
Issue:		6
Page Number:		557 - 565
DOI:		10.1038/nn0602-859
ISSN/ISBN:		1097-6256 (Print) 1097-6256 (Linking)
Abstract:		"At the first stage of olfactory processing in the brain, synchronous firing across glomeruli may help to temporally bind multiple and spatially distributed input streams activated by a given odor. This hypothesis, however, has never been tested in an organism in which the odor-tuning properties of several spatially identifiable glomeruli are known. Using the sphinx moth, an insect that meets these specific criteria, we recorded odor-evoked responses simultaneously from pairs of projection neurons (PNs) innervating the same or different glomeruli in the macroglomerular complex (MGC), which is involved in processing pheromonal information. PNs that branched in the same glomerulus and were activated by the same pheromone component also showed the strongest coincident responses to each odor pulse. Glomerulus-specific PN pairs were also inhibited by the pheromone component that selectively activated PNs in the neighboring glomerulus, and about 70% of all intraglomerular pairs showed increased synchronization when stimulated with a mixture of the two odorants. Thus, when two adjacent glomeruli receive their inputs simultaneously, the temporal tuning of output from each glomerulus is enhanced by reciprocal and inhibitory interglomerular interactions"
Keywords:		Animals Electric Stimulation Male Manduca Neural Inhibition/*physiology Neurons/*physiology Odorants Olfactory Pathways/cytology/*physiology Pheromones/chemistry Smell/*physiology Synaptic Transmission/physiology Time Factors;
Notes:		"MedlineLei, Hong Christensen, Thomas A Hildebrand, John G eng R01 DC002751/DC/NIDCD NIH HHS/ Research Support, U.S. Gov't, P.H.S. 2002/05/15 Nat Neurosci. 2002 Jun; 5(6):557-65. doi: 10.1038/nn0602-859"