| Title: | The maternal pheromone and bile acids in the lactating rat |
| Author(s): | Kilpatrick SJ; Bolt M; Moltz H; |
| DOI: | 10.1016/0091-3057(80)90188-4 |
| ISSN/ISBN: | 0091-3057 (Print) 0091-3057 (Linking) |
| Abstract: | "Bile was drawn from virgin rats and from postpartum rats that were with young for 5, 12, 21, and 30 days, respectively. The bile thus drawn was analyzed enzymatically after chromatographic separation to test an hypothesis relating cholic acid and one of its metabolites, deoxycholic acid, to the appearance of the maternal pheromone. Our finding that cholic acid, but not deoxycholic acid, reached a peak that was tied specifically to the period of pheromonal emission led us to advance a revised hypothesis. We now think that cholic acid alone, or more likely a cholic metabolite other than deoxycholic acid, underlies the appearance of the pheromone" |
| Keywords: | Animals Bile/metabolism Bile Acids and Salts/*metabolism Chenodeoxycholic Acid/metabolism Cholic Acids/metabolism Deoxycholic Acid/metabolism Female *Lactation *Maternal Behavior Pheromones/*metabolism Pregnancy Rats Time Factors; |
| Notes: | "MedlineKilpatrick, S J Bolt, M Moltz, H eng Research Support, U.S. Gov't, P.H.S. 1980/04/01 Pharmacol Biochem Behav. 1980 Apr; 12(4):555-8. doi: 10.1016/0091-3057(80)90188-4" |
