| Title: | Let Me Upgrade You: Impact of Mobile Genetic Elements on Enterococcal Adaptation and Evolution |
| Author(s): | Johnson CN; Sheriff EK; Duerkop BA; Chatterjee A; |
| Address: | "Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA" |
| ISSN/ISBN: | 1098-5530 (Electronic) 0021-9193 (Print) 0021-9193 (Linking) |
| Abstract: | "Enterococci are Gram-positive bacteria that have evolved to thrive as both commensals and pathogens, largely due to their accumulation of mobile genetic elements via horizontal gene transfer (HGT). Common agents of HGT include plasmids, transposable elements, and temperate bacteriophages. These vehicles of HGT have facilitated the evolution of the enterococci, specifically Enterococcus faecalis and Enterococcus faecium, into multidrug-resistant hospital-acquired pathogens. On the other hand, commensal strains of Enterococcus harbor CRISPR-Cas systems that prevent the acquisition of foreign DNA, restricting the accumulation of mobile genetic elements. In this review, we discuss enterococcal mobile genetic elements by highlighting their contributions to bacterial fitness, examine the impact of CRISPR-Cas on their acquisition, and identify key areas of research that can improve our understanding of enterococcal evolution and ecology" |
| Keywords: | Biological Evolution CRISPR-Cas Systems Enterococcus faecalis/*genetics Enterococcus faecium/*genetics Interspersed Repetitive Sequences/*genetics Crispr antibiotic resistance enterococci horizontal gene transfer mobile genetic elements phage pheromone-re; |
| Notes: | "MedlineJohnson, Cydney N Sheriff, Emma K Duerkop, Breck A Chatterjee, Anushila eng F31 AI157050/AI/NIAID NIH HHS/ R01 AI141479/AI/NIAID NIH HHS/ T32 AI052066/AI/NIAID NIH HHS/ R01AI141479/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Review 2021/08/10 J Bacteriol. 2021 Oct 12; 203(21):e0017721. doi: 10.1128/JB.00177-21. Epub 2021 Aug 9" |
